DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG4459

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	114/578 - (19%)
Similarity:	235/578 - (40%)	Gaps:	98/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DILVEI-GEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWVS 80
            |::.:: |.|||:|.|..|||.|..:.:|..:...::||..|                    |..
  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYP--------------------WKG 63

  Fly    81 --IAVPGSWS---------KRGH------------FTPSTCERF---VANGDHLESSSDPWSAWP 119
              :..|..|:         .|.|            |....|..:   :|.| .:.|....|:|..
  Fly    64 ELVCHPADWNVSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARG-FVRSHGQEWNASQ 127

  Fly   120 LDQCFAENFTTETERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLA 184
            ..:...::    :..|....:.:..::::.|:.|.|...: .:|...:.|..|.::|..::....
  Fly   128 SKEPGGQS----SLPCEHVEHRTDYKSLISQFDLICSRRV-LVALTQSFHALGALIGGLMAYSAL 187

  Fly   185 DRYGRKHIFLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREM 249
            .:...:.:.|..::.....|....|...|...::|..|.::..:.:|.....|..::...:.|.:
  Fly   188 KKISPRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARII 252

  Fly   250 SSIVLNYFYAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWL---VPESVRWLLARNRREQ 310
            ...:...|:::|..|| .:|::..:|..|.:|:|...::.|   ||   :.::.||||...|.|.
  Fly   253 VVTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLV---WLHRWIADAPRWLLQHQRVEA 314

  Fly   311 AGVIIRRAAKVNRRDI--SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHI 373
            |...:..:|..|.|.:  ::::..:....:||.::.|:...         .::|..  |..||.:
  Fly   315 ALRQLLESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSY---------CQVWDG--ETKRSQL 368

  Fly   374 LMGRYAILLLIWAVNAIVYYGLSLNATSLSGNK-YLNFALVCLVEIPGYSLAW---LFLRRFGRR 434
            :     .:.|||....::|..:.|...:|...: ::|.|.:...|:.|..:..   |:.||..|
  Fly   369 V-----YIHLIWGGAMVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWR- 427

  Fly   435 VALSGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVI 499
              .:|:|:      :.:|..|..  .|:..:|...||..     .|.:..:|:.|:..::|.||:
  Fly   428 --WAGNLM------IIAGLSTYL--IWLLPETERNSRRV-----GLELVFWLILKIANSASIAVL 477

  Fly   500 YTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGL 557
            .|.|:|::....|...:..:.:|:|...:..||:..|...:..:|:.:..|:..:.||
  Fly   478 TTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	113/571 (20%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	77/384 (20%)
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	113/571 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	83/407 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950