DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG6126

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	175/577 - (30%)
Similarity:	276/577 - (47%)	Gaps:	74/577 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECD--KLVDAEYGANW 78
            :|::.::||||::|...:.|..|..|.|..:.||.|..|..|.:||::...|  .|....:.::.
  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSA 72

  Fly    79 VSIAVPGSWSKRGHFTPSTCERFVANGDHLES--SSDPWSAWPLDQCFAENFTTETERCNQFVYG 141
            :..|:|                ...||: |||  ..||.|..          |..|..|.::||.
  Fly    73 ILAAIP----------------LKPNGE-LESCLMFDPSSPG----------TNTTINCERYVYD 110

  Fly   142 S----SERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMAL 202
            :    :.|||  .|...| :..|..|.|.|:...|:..|....|.|||:.|||.:|.:..:|..:
  Fly   111 TTYYKTSRTI--DWNFVC-DRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLI 172

  Fly   203 TGVAQALSWDYISFLFFA-LLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL- 265
            .||..|...:|.||:... ||..||::|.|...|::.:|:|||.||.:..|.....:|.|..|:
  Fly   173 IGVGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVA 237

  Fly   266 GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVEL 330
            |....:||.:.||:...:...:.:.::|.:.||.|||..:.|..:|..|:.:..::|...|.|:
  Fly   238 GWGALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVD- 301

  Fly   331 MASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395
             ..:..|:...:...|:....||            .::.|:..|..:...:.|.|..|::|||||
  Fly   302 -KEYYVQKAKQQAAAEEKSSAGL------------SDLFRTPNLRMKTLNVCLCWFANSLVYYGL 353

  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460
            ||:|..|.||.||...::.|||.|.|......|.|.|||...|..:|...:.|:.:.::  |||
  Fly   354 SLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYI--AQG- 415

  Fly   461 WIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFARF 525
                          |..:..||   :.|||.|..||||||.::||:.|||:|:..:|:.|..||.
  Fly   416 --------------STTSTAVV---MAGKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARL 463

  Fly   526 GAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582
            ...|.|.:.||.|:...:|.:|||.::|::|...:.||||.|:.:|:::|:....||
  Fly   464 SGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGENFGK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	171/559 (31%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	118/376 (31%)
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	170/558 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	127/404 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	7.070