DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG14857

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	135/591 - (22%)
Similarity:	239/591 - (40%)	Gaps:	94/591 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICL--------PVLFAAANSLSYVFTAGSPTYRCYVPECDKL 69
            :|||.||.:.|..||:|   ||:|.|        .|.:.:.|.:.:|     |.:.||....:..
  Fly     1 MDFDQILEKCGSAGRYQ---YLMILLLGYIAFTTTVHYYSQNIIGFV-----PQHWCYHEALENR 57

  Fly    70 VDAEYGANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETER 134
            ...|..|.:.......|           |.|                   ||:...:..|...|.
  Fly    58 SFEEIAAIYAPFGKEAS-----------CTR-------------------LDKIEGDRVTVSNET 92

  Fly   135 CNQFVY----GSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLF 195
            |.:::|    |.........|  .| .:.:|.....::.|.|.::||...|.|.||.||....:.
  Fly    93 CQRWIYNYDFGFRSMNAELNW--VC-NDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVIL 154

  Fly   196 C----IVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMS-SIVLN 255
            .    .|...||..|..|    :.|..|..::.:..:..|.|.||:.:|.:.|:.|.|: |..|.
  Fly   155 ANQCGFVGDFLTTYASNL----VQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLG 215

  Fly   256 YFYAVGEALLG--LSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRA 318
            ..:.:| ||:.  |||...:||......::..|:...::::|.||.:||:.|...|.|...::..
  Fly   216 ICFCLG-ALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHI 279

  Fly   319 AKVNRRDISVELMASFKQQELDAE--TGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAIL 381
            |..|..::......:|::..:...  :.|.:...|             :.::.|:..|.....::
  Fly   280 AHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQTAG-------------IFDLLRTPNLRKVSLLV 331

  Fly   382 LLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSI 446
            :..:.:.::.:..:|.|...:..:.::.|:|..:|..|...:..|...|.||:.....::|...:
  Fly   332 VFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGL 396

  Fly   447 TCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVI 511
            ...|.|.....:|    .|..|.          |::...|..:|||:..:.|...|.:|::||.:
  Fly   397 LSCALGVALSTEG----AQKNVT----------LLLAFALPMRLGISMCYTVTSQFASELLPTCV 447

  Fly   512 RSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            ||.|:..:...|...:.::|::..|.:.....|.|:...|.|.|...:|:||||.||:||.|:.:
  Fly   448 RSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLAD 512

  Fly   577 AIALGK 582
            ..|.||
  Fly   513 GEAFGK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	126/570 (22%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	83/383 (22%)
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	126/570 (22%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	82/375 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	4.990