DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG14856

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	151/587 - (25%)
Similarity:	263/587 - (44%)	Gaps:	83/587 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVL--------FAAANSLSYVFTAGSPTYRCYVPECDKL 69
            :|||:|||:.|:..|:|   |:|:.|..|        :.|.|.:.:|     |.:.||..:.:..
  Fly     3 MDFDEILVKCGDSHRYQ---YMLLALYGLLMFIVSRHYFAQNVIGFV-----PDHWCYHEQLENR 59

  Fly    70 VDAEYGANWVSIAVPGSWSKRGHFTPSTCERFVA-NGDHLESSSDPWSAWPLDQCFAENFTTETE 133
            ..||..|    |..|        |...:|.|..: |.|                  ..|.|..:|
  Fly    60 SYAEIAA----IYAP--------FKRPSCTRLASINMD------------------GSNATASSE 94

  Fly   134 RCNQFVYGSSERTIVQQWGLQ--CPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGR-KHIFLF 195
            .||:::|......|.....|.  | ::.:|.....::.|.|.:.||.|.|.|.||.|| |.:.|.
  Fly    95 PCNRWIYHYDHGFISMNADLNWVC-DDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLA 158

  Fly   196 -CIVFM--ALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMS-SIVLNY 256
             |..|:  :.|..|:.|    ::|.....::.:.......|.||:.:|.|.|..|.:. ::.:..
  Fly   159 NCCGFLGDSATIFAETL----LTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCV 219

  Fly   257 FYAVGEALLG-LSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAK 320
            ||.:|..... ..|:|..||...:..::|.|:...:::|:.||.:||:.|...:.|.:.:||.||
  Fly   220 FYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAK 284

  Fly   321 VNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIW 385
            .||||:|......|:|.   .:| :|.:....:.::|..::..:.| :.|..:   |...:.:::
  Fly   285 FNRRDVSEADYELFRQH---CKT-KESEARSQMSMQKQARLIDSFK-LPRLRL---RLIYVTVVF 341

  Fly   386 AVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVA 450
            ::..:.|..:|.|...||.:.::.|:|..|...|.........:.|||:       ....::..|
  Fly   342 SIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRK-------FTSVVSMTA 399

  Fly   451 SGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGG 515
            :|.:|...|..:...|    :||.:    ::|.|.|:.:.||:.:.......:.|:|||.:||.|
  Fly   400 TGLMTATTGILLAFWT----QHSAT----VMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSG 456

  Fly   516 VGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIAL 580
            :.|:...|...:.::||:..|.:|:.....::...|.||:..:.|||.||.|:|||.|:.|....
  Fly   457 LAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEF 521

  Fly   581 GK 582
            ||
  Fly   522 GK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	141/566 (25%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	94/380 (25%)
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	141/566 (25%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	100/400 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	4	3.940