DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	573	Identity:	161/573 - (28%)
Similarity:	266/573 - (46%)	Gaps:	60/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWV 79
            |.|:|.::|..||||..:..|:.:|:|..|:::|...|.|..|.:.|. |..:..:.:....:.:
Zfish     3 FSDLLEQVGSTGRFQVLHVTLLSMPILMMASHNLLQNFVAAVPPHHCQ-PHANLSMSSTDAMDVL 66

  Fly    80 SIAVP----GSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-FV 139
            ...||    |...:        |:|:......:.|.:...|.|  |:..||   |||:.|.. :.
Zfish    67 RATVPLGLNGKLER--------CKRYTTPQWQILSLNTSESLW--DESMAE---TETQSCEDGWF 118

  Fly   140 YGSSE--RTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMAL 202
            |..:|  .||:.:|.|.|.....| ....|.:..|::||..:.|.|:||:||:.:.|...:.||:
Zfish   119 YNMTEMSSTIITEWDLVCDYRALK-QMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAI 182

  Fly   203 TGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALLGL 267
            .|...|.|..:..|..|.:...:..||:...:|.:.||.:..|.|.:......|.|..|:.:|..
Zfish   183 GGTCVAFSTSFTMFCVFRVCCGMALSGLVLNSFSLIVEWIPTRVRTVVGTGTGYCYTTGQLILAA 247

  Fly   268 SVF-LPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVELM 331
            ..: :.|||.|.||:|:|..:...|.|...||.|||:...:.|||...::..|::|.|
Zfish   248 VAYCIRDWRWLTLAVSLPFYVSFLYSWWFLESARWLVLTKKPEQAVKNLKTVARINGR------- 305

  Fly   332 ASFKQQELDAETGQEDDVEGGLHVKKD---DKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYY 393
             |.:..::|.|..||.       :||:   .|...:..::.|:..:......|..:|...:..||
Zfish   306 -SAEGDKIDLEMLQES-------MKKEMACSKGSYSALDLLRTSTMRTITICLSAVWFSTSFAYY 362

  Fly   394 GLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQ 458
            |||::......:.||...:...|:||...:..:.:...|||.:..|:|:|..|..:.:..|.
Zfish   363 GLSMDLQKFGVSIYLIQIIFGAVDIPAKIIVTICMSMLGRRPSQCGALVLAGIMILINLLVP--- 424

  Fly   459 GDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFA 523
                            |....|..:|.::||..:.:||...|.:..|:.|||||..|:|.:|..|
Zfish   425 ----------------SDLQMLRTSLAVIGKGCLAASFNCCYLYAGELYPTVIRQSGMGWVSMMA 473

  Fly   524 RFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            |||||:||.|.||...|..:|..::|...:|:|:.:..||||.::.||||:::
Zfish   474 RFGAMVAPMVLLLGDDYPWIPGFIYGGAPIVSGIFAFFLPETLSQPLPDTIQD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	156/560 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	105/378 (28%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	156/560 (28%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	120/431 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030