DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a4

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_989323.1	Gene:	slc22a4 / 394948	XenbaseID:	XB-GENE-5858686	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	595	Identity:	186/595 - (31%)
Similarity:	297/595 - (49%)	Gaps:	110/595 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW 78
            |:|:....:||:||:|...:.|:...::....|.:|.:|.||.|.:||::||     .|...|.|
Frog     3 DYDEATSFLGEWGRYQFMIFFLLSASIIPNGFNGMSVMFLAGIPEHRCHIPE-----SANLSAAW 62

  Fly    79 VSIAVPGSWSKRGHFTPSTCERF----VAN---------------GDHLESSSDPWSAWPLDQCF 124
            .:.::|     |.....|.|.|:    :.|               |...|...|.|
Frog    63 RNASIP-----RQDGQDSQCRRYRLGTLTNYSALGLLPGRDVDVTGIEQEPCLDGW--------- 113

  Fly   125 AENFTTETERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGR 189
              |:       ::.:|.|   |||.:|.:.| ||.||.....::.|.|:::|:.:||.|:|.:||
Frog   114 --NY-------SKSLYLS---TIVTEWDIVC-ENDWKGPLTTSLFFVGVLLGSFVSGQLSDSFGR 165

  Fly   190 KHIFLFCIVFMALTGVAQ--ALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREM-SS 251
            |.|....:.......:.|  :.||:..:.||  |:..:|....|..|||:|.|::|...|.: |:
Frog   166 KKILFVTMAIQTGFSIVQVFSTSWEMFAILF--LIVGMGQISNYVAAFILGTEILGKSARIIFST 228

  Fly   252 IVLNYFYAVGEALLGL-SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVII 315
            :....|:|:|..:|.| :.|:.|||.|.|||::|.|.|:..:|::|||.:||:.:.|.|:|.|||
Frog   229 LGTCIFFAIGYMMLPLFAYFIRDWRTLLLALTIPGLFCIPLWWIIPESPQWLICKGRLEEAEVII 293

  Fly   316 RRAAKVNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRY-- 378
            |:|||:||......:   ||..||      ||..|                ...||:.|:...
Frog   294 RKAAKINRVPAPAVI---FKTTEL------EDIAE----------------RQKRSYTLLDLVKT 333

  Fly   379 -------AILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVA 436
                   .:.:.:|.:.:|.|:|:|||..:|.|:.:||..|:..:|:|....|||.||...||.:
Frog   334 FNVRIITIMTVFLWLITSIGYFGISLNTPNLHGDPFLNCFLLAAIEVPSNIFAWLLLRYISRRYS 398

  Fly   437 LSGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYT 501
            :.|||||        |.|.|.....:|....:           |...|.:|||.|:|::|:::|.
Frog   399 MCGSLLL--------GGVVLLLIQLVPLDLQI-----------LSTVLVMVGKFGVTAAFSMVYV 444

  Fly   502 FTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETF 566
            :|||:.|||||:.|||:.|..:|.|::::|:...|.:|...||.:|.|:|::..|:|.|..||||
Frog   445 YTAELYPTVIRNTGVGIGSVSSRIGSVISPYFVYLGAYNRLLPYILMGSLTVANGILVLFFPETF 509

  Fly   567 NRKLPDTVEE 576
            .:.||:|:|:
Frog   510 GKPLPETIEQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	182/581 (31%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	128/387 (33%)
slc22a4	NP_989323.1	2A0119	12..516	CDD:273328	182/581 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.100