Protein Alignment CG4630 and SLC22A10

DIOPT Version :10

• Sequence 1: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001034841.3
• Gene: SLC22A10 / 387775
• HGNCID: 18057
• Length: 541
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 155/600 - (25%)
• Similarity: 266/600 - (44%)
• Gaps: 111/600 - (18%)

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN-- 77
            |:::|.::|..||||..:.:.|...::....:.|...|.|..|.:||:|    .::|...|:.
Human     3 FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWV----HMLDNNTGSGNE 63

  Fly    78 --------WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETER 134
                    .:.|::|...:.|    |..|.|||    |.:     |....|:.........:||.
Human    64 TGILSEDALLRISIPLDSNLR----PEKCRRFV----HPQ-----WQLLHLNGTIHSTSEADTEP 115

  Fly   135 C-NQFVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFC 196
            | :.:||..|  ..|||.:|.|.|.....| :.|..:...|::||..:.|:::||:||:.|..:|
Human   116 CVDGWVYDQSYFPSTIVTKWDLVCDYQSLK-SVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWC 179

  Fly   197 IVFMALTGVAQALSWDYISFLFFALLNAVGTSGVY-PLAFIIG--------------VEMVGPRK 246
            ::.:|:|....|.:               .|..|| .|.|:.|              .|.:.|..
Human   180 LLQLAITDTCAAFA---------------PTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNS 229

  Fly   247 REMSSIVLNYFYAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYF----WLVPESVRWLLARN 306
            :.:..|:.:...::|:.:| ||:....||:.|.:..|||..:   :|    ||| ||.|||:..|
Human   230 KALVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFV---FFLLSRWLV-ESARWLIITN 290

  Fly   307 RREQAGVIIRRAAKVN-----RRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVK 366
            :.::....:|:.|:.|     ...:::|::.|..|:||||...:                 ..|.
Human   291 KLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTK-----------------TTVC 338

  Fly   367 EVARSHILMGRYAILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRF 431
            ::.|:..:..|..||:.:...|.|.:||..:|...:..|.:|...|...|.:....||.|.|...
Human   339 DLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHM 403

  Fly   432 GRRVALSGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSF 496
            |||::....:.|..::.:|:.||....      ||             |.|.|..:|.....::|
Human   404 GRRISQILFMFLVGLSILANTFVPKEM------QT-------------LRVALACLGIGCSAATF 449

  Fly   497 AVIYTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLL 561
            :.:.....|::|||:|:...|:..|.:|.||.|||.:..|..::..||.:::|...::.||:..|
Human   450 SSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFL 514

  Fly   562 LPETFNRKLPDTVEE 576
            ||||.|..||||:::
Human   515 LPETKNLPLPDTIKD 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	151/587 (26%)
SLC22A10	NP_001034841.3	MFS_OAT	109..516	CDD:340932	118/462 (26%)