DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG42269

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	167/593 - (28%)
Similarity:	282/593 - (47%)	Gaps:	92/593 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLIC-LPV-LFAAANSLSYVFTAGSP-TYRCYVPECDKL-VDAE 73
            :||||||..||||||:|:  .|.|| :|. .|.|....|.:|....| .:.|:|||.|.| |:|.
  Fly    70 MDFDDILPLIGEFGRYQK--LLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEAR 132

  Fly    74 YGANWVSIAVPGSWSKRGHFTPSTCERFVANGDHL----ESSSDPWSAWPLDQC---FAENFTTE 131
                 :::::|   ...|.:  :.|..:..|...:    :..:||  .||..:|   ::.|||
  Fly   133 -----LALSIP---MTNGEY--NNCYMYDVNYTDILAQGKVMADP--KWPQVKCRHGWSYNFT-- 183

  Fly   132 TERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFC 196
                 :..|.    |:..:....|.:.... .:..:|.|.|.:||..|.|::|||:||....:..
  Fly   184 -----EIPYA----TVATEQNWVCDDAALP-TYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGT 238

  Fly   197 IVFMALTGVAQAL---SWDYISFLFFALLNAVGTS--GVYPLAFIIGVEMVGPRKRE-MSSIVLN 255
            .:...|.||..|.   .|::....||     ||.:  ..:.:.:|:.:|.|||:.|. ::::.:.
  Fly   239 NMMGLLAGVGTAFVSNFWEFAIMRFF-----VGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIA 298

  Fly   256 YFYAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAA 319
            .|:.....|| .::.||.||:.|.:..|.|.|:.:...::||||.|||:::.:.::|..|:::..
  Fly   299 IFFTGAACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLE 363

  Fly   320 KVNRRDISVELMASF-----KQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYA 379
            |.|.|.:..:....|     :.||.:|:.|:                 .:|.::.:|..|.....
  Fly   364 KGNGRQVPPQTYQIFTDSCKRMQEQEAQNGK-----------------YSVLDLFKSPRLRRTTL 411

  Fly   380 ILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLC 444
            :|::||...::|:.|...|..||..:.:..|.|.|..|:|..:|..:.|.|||||      .|.|
  Fly   412 LLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRR------WLAC 470

  Fly   445 SITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPT 509
            |...::..|..||  ..:|  .|:.|           ..|.::|:..:..|:.:...:.||::||
  Fly   471 SSMVLSGVFSLLA--TVVP--VGIYS-----------AALAIMGRFFVNISYNIGLQWAAEVLPT 520

  Fly   510 VIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTV 574
            |:|:..|..:.......:::||||..||:....|||::.|.|.::.|||:||||||.|..||.|:
  Fly   521 VVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPETLNHVLPQTL 585

  Fly   575 EEAIALGK 582
            .:....|:
  Fly   586 SDGEEFGR 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/572 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	99/386 (26%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	141/540 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	100/381 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458520
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.890