DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	582	Identity:	164/582 - (28%)
Similarity:	274/582 - (47%)	Gaps:	68/582 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWV 79
            |.|:|..:|..||||.....|:.||....|.::....|||.:|.:.|..|.............|:
Mouse     3 FTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEPTTNVSGVWL 67

  Fly    80 SIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-FVYGSS 143
            ..|:|    ...|..|..|.|:|          :|  .|.|.:..|.:....||.|.. :||..|
Mouse    68 RAAIP----LNQHGDPEPCRRYV----------EP--QWALLKPNASSHGVATEGCKDGWVYDRS 116

  Fly   144 --ERTIVQQWGLQC-PENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTGV 205
              ..|||.:|.|.| ...|..||  .:|:.:|::||.||.|.||||.|||...::..:.:|::|.
Mouse   117 IFPSTIVMEWDLVCEARTLRDLA--QSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGA 179

  Fly   206 AQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL-GLSV 269
            |.|....:.::..|..|..:..||:...:..:.||.:..|.|.::.|:|.:.:.:|:.:| |::.
Mouse   180 ATAYVGSFSAYCVFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAY 244

  Fly   270 FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRD-----ISVE 329
            .:..||.||.|:|.|.|:...|.|.:|||.||||...:.:||...:::.|.:|.|.     ::.|
Mouse   245 LIRPWRWLQFAVSAPFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGERLTTE 309

  Fly   330 LMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYG 394
            :::|:.|.|..:             |:..:    ::.::.|:..:......|:.:|..|::.|||
Mouse   310 VVSSYIQDEFAS-------------VRTSN----SILDLFRTPAIRRVTCCLMGVWFSNSVAYYG 357

  Fly   395 LSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQG 459
            |:::......:.||..||..:::||...:|...:...|||..:|..|:|..:..:|:.|:
Mouse   358 LAMDLQKFGLSIYLVQALFGIIDIPAMLVATTTMIYVGRRATVSSFLILAGLMVIANMFM----- 417

  Fly   460 DWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFAR 524
                 ...:::..:...|         :||..:.|||..:|.||.|:.||.||..|:|..|..||
Mouse   418 -----PEDLQTLRTVQAA---------LGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVNAR 468

  Fly   525 FGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGL-LSLLLPETFNRKLPDTV---EEAIALGK 582
            .|.::||.:..|......||.:.||..|::||: ::..|.||.|..|.:|:   |..:..|:
Mouse   469 LGGLVAPLITTLGEISPVLPPVSFGATSVLAGMAVACFLTETRNVPLVETIAAMERRVKQGR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/560 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	106/380 (28%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	158/560 (28%)
		MFS	138..507	CDD:119392	113/406 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.960