DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG8654

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	164/578 - (28%)
Similarity:	268/578 - (46%)	Gaps:	114/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWVS 80
            |.|:.:||:|.|:|...:.::.|                                 .::|..|.:
  Fly    22 DPIISQIGDFRRYQLFFFFIVLL---------------------------------CKFGTGWHT 53

  Fly    81 IAVPGSWSKRGHF-----TPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQFVY 140
            :         ||.     ||.:|:        .|:.:||.|    |:|....|.|.       |:
  Fly    54 L---------GHIFLAAPTPLSCK--------TENVTDPCS----DECSETEFDTS-------VF 90

  Fly   141 GSSERTIVQQWGLQCPENLWKLAFVG-TIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTG 204
            .|   ||:.:|.|.|...  :||.:. :|...|::.|:.|.|..||||||:..||.|.....:||
  Fly    91 QS---TIITEWNLTCESK--QLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITG 150

  Fly   205 VAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALLGL-S 268
            :...:|..|..:..|..|.||.|:|....:|::.:|:|||:||||.:|:....:.:|.|.|.| :
  Fly   151 LIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFA 215

  Fly   269 VFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNR---RDISVEL 330
            .|:.:||..|.::::..::.|.|.||||||.|||....:.:::..|:.:.||.|:   ..|..|:
  Fly   216 YFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEI 280

  Fly   331 MASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395
            .|::                |.|..::..|....| ::.|:..:..:...:...|.|..:||||.
  Fly   281 EAAY----------------GALAARQPVKKGTVV-DLFRTPYMRIKTIFMANNWLVVCMVYYGT 328

  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460
            :...::|.||.:::.|:...|.|||..|..|..:..||:     ..||.|..|.|.|.:.||
  Fly   329 AQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK-----KTLLLSNGCSALGLILLA--- 385

  Fly   461 WIPC-QTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFAR 524
               | .|..|:         :.||...:|..|.:.:|..:|.:..|:.|||:||.|||:.|...|
  Fly   386 ---CLSTQAEA---------VRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGR 438

  Fly   525 FGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582
            .|:::||.:..||:|...:..|:||..|::|.|.::.||||....||:|:|:....|:
  Fly   439 IGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGETFGR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/560 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	116/380 (31%)
CG8654	NP_001246441.1	SP	85..487	CDD:273317	140/450 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	133/438 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.970