DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	170/596 - (28%)
Similarity:	262/596 - (43%)	Gaps:	113/596 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPV---LFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEY 74
            ::.::....:||.|.:|.  ||...|.|   |:.|..::.......:|.|...:.|
  Rat     1 MEVEEAFQAVGEMGLYQM--YLCFLLAVLLQLYVATEAILIALIGATPAYHWDMAE--------- 54

  Fly    75 GANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSA---WPLDQCFAENFTTETERCN 136
                                      .:.|..|...||....|   |.|        |......:
  Rat    55 --------------------------LLPNQSHSNQSSGKGQAFGDWLL--------TANGSEIH 85

  Fly   137 QFVYGSSERT-IVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFM 200
            :.|:.|:..| |..:|.| .....:|::...:..|:|:.||....|.|:||:|||.::|......
  Rat    86 KHVHFSNSFTSIASEWFL-IANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149

  Fly   201 ALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG---E 262
            .|..:|...|..|..|.....|..:...|:..:||::..|.||.....::..:...|:|||   .
  Rat   150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQY 214

  Fly   263 ALLGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDIS 327
            ||||  .|:..||.|.:.:::...:.......:|||.|||.::.|..:|...:...||.||: :.
  Rat   215 ALLG--YFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK-LK 276

  Fly   328 VELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVY 392
            .....:........|||                   :..::.|..:|:|...||:.||.|.::||
  Rat   277 CTFSLTHPANRSYRETG-------------------SFLDLFRYRVLLGHTLILMFIWFVCSLVY 322

  Fly   393 YGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFL---RRFGRRVALSGSLLLCSITCVASGFV 454
            |||:|:|..|.|:.|.|.||..|:|||.|.|. ::|   |.|||:..|:..|.|..:.|:...|:
  Rat   323 YGLTLSAGDLGGSIYANLALSGLIEIPSYPLC-IYLINQRWFGRKRTLAAFLCLGGLACLIVMFL 386

  Fly   455 TLAQGDWIPCQTG---VESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGV 516
            ...:      .||   |.:.||          |.|:|||.|:::|.::|.:|:|:.|||||:.|:
  Rat   387 PEKK------DTGVFAVVNSHS----------LSLLGKLTISAAFNIVYIYTSELYPTVIRNVGL 435

  Fly   517 GVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTV------- 574
            |..|.|:|.|.::|||||.|......||.::||...|.:||||||||||.|..|.:|.
  Rat   436 GTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQMYS 500

  Fly   575 -----EEAIAL 580
                 |||::|
  Rat   501 YRRLGEEALSL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	165/565 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	117/383 (31%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	123/396 (31%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	114/377 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930