DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	149/595 - (25%)
Similarity:	258/595 - (43%)	Gaps:	101/595 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYV---FTAGSPTYRCYVPECDKLVDAEYG- 75
            ||:||..:|:.||||  .::::.|.:| :..:||..|   |||..|.:.|.|    .|:|....
  Rat     3 FDEILHHVGDRGRFQ--IWMIVVLNIL-SMVSSLHDVIENFTAAIPAHHCSV----NLLDTSRSE 60

  Fly    76 ---------ANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTT- 130
                     ...:.:::|...:::    |..|.||               ..|..|....|.:|
  Rat    61 ISMAMNLTTEAMMKVSIPMGPNQK----PEQCRRF---------------RHPQWQFIDSNISTS 106

  Fly   131 -----ETERC-NQFVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRY 187
                 |||.| :.:.|..|  ..|||.:|.|.|....:|. :......||..|.....|.::||:
  Rat   107 NSTELETEPCLDGWTYDHSVFTSTIVTEWDLVCDFQSFKY-YAQATSLAGHFVAAPFCGIISDRF 170

  Fly   188 GRKHIFLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSI 252
            |||.:.::|.:...:.|...|...::..:.....|::...|.|.....|:.:|....:......:
  Rat   171 GRKPLLMYCSLAYGILGTCCAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWHATVIV 235

  Fly   253 VLNYFYAVGEA-LLGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIR 316
            :...|.:.|.| |.||:..|.||..:||..::|..|....|..||||.|||:...:.:||...::
  Rat   236 LSGLFSSTGLAGLGGLAYVLSDWHLIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQ 300

  Fly   317 RAAKVN-RRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAI 380
            |.|.:| ::||:         |.|..|         .|..|..:.:...||..:...|::.. .|
  Rat   301 RIASINGKKDIA---------QNLTTE---------DLRSKVKEDVCSTVKHFSIKDIIINP-MI 346

  Fly   381 LLLIWAVNAIVY------YGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSG 439
            ..::...:::::      :||.|:...|..|.::...|:.:::||..||.:..||...|| .|..
  Rat   347 RKIVLCYSSVLFAELFSIFGLLLDVHMLGKNIFVTQILLGVIDIPSKSLTYFILRNVRRR-PLIA 410

  Fly   440 SLLLCSITCVASGFVT--LAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYT- 501
            .||..:..|:.   :|  |::..::                 |.:.:|::|| |..::|..|.|
  Rat   411 FLLFATGGCIT---ITMFLSEDMYV-----------------LRLAIFILGK-GCFAAFISINTA 454

  Fly   502 FTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETF 566
            :..|:.|..:||...|:..:.||..::|:....:...|:..||::..|.|.:||.:....|||||
  Rat   455 YCNELSPVPLRSTLNGIYISVARLASVLSALTLVTRKYFVLLPMIFCGVLPIVATINIYFLPETF 519

  Fly   567 NRKLPDTVEE 576
            |..:.||:::
  Rat   520 NHPITDTIKD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	143/582 (25%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	91/385 (24%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	143/582 (25%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	104/430 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950