DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	173/580 - (29%)
Similarity:	276/580 - (47%)	Gaps:	63/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78
            ||:|.::||||.||::.:||:||.....|...:..||...:|.:.|..|   .:.:......|
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNP---GVAELSQRCGWSQ 66

  Fly    79 ---VSIAVPG-SWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-F 138
               ::..||| ..|....|. |.|.|:..  |..:|:.|  ...||....|.........|.. :
  Rat    67 AEELNYTVPGLGPSDEASFL-SQCMRYEV--DWNQSTLD--CVDPLSSLVANRSQLPLGPCEHGW 126

  Fly   139 VYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALT 203
            ||.:...:||.::.|.|.: .||:....:....|..:|:.:.||:|||:|||...|...:..:::
  Rat   127 VYDTPGSSIVTEFNLVCGD-AWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVS 190

  Fly   204 GVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG-EALLGL 267
            ||..|::.||.|.|.|.||..:.:.|.:...:.:..|.||...|..::|:....:.|| ..|.|:
  Rat   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGV 255

  Fly   268 SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR----DISV 328
            :..:||||.||||:|:|..:.:.|:|.||||.||||::.|..:|..|:.:.|:.|.:    |:.:
  Rat   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKM 320

  Fly   329 ELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYY 393
            ..:              |:|.        .:|...:..::.|:..|.....||:.:|...|::|.
  Rat   321 LCL--------------EEDA--------SEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQ 363

  Fly   394 GLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQ 458
            ||.::..:...|.||:|....|||.|...:..:.:.|.||...::.|.|:....|:...|:.
  Rat   364 GLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIP--- 425

  Fly   459 GDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFA 523
                         |.   .:||.|||..:|::|.|....::....||:.||.||:.|:.|.|...
  Rat   426 -------------HE---LHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALC 474

  Fly   524 RFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582
            ..|.:..||:.. |...:..|||:|||.|.|.||.::||||||....||:|:|||..||:
  Rat   475 DLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/562 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	106/379 (28%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	164/562 (29%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	126/431 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860