Protein Alignment CG4630 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_036829.1
• Gene: Slc22a1 / 24904
• RGDID: 3224
• Length: 556
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 173/580 - (29%)
• Similarity: 276/580 - (47%)
• Gaps: 63/580 - (10%)

  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78
            ||:|.::||||.||::.:||:||.....|...:..||...:|.:.|..|   .:.:......|
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNP---GVAELSQRCGWSQ 66

  Fly    79 ---VSIAVPG-SWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-F 138
               ::..||| ..|....|. |.|.|:..  |..:|:.|  ...||....|.........|.. :
  Rat    67 AEELNYTVPGLGPSDEASFL-SQCMRYEV--DWNQSTLD--CVDPLSSLVANRSQLPLGPCEHGW 126

  Fly   139 VYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALT 203
            ||.:...:||.::.|.|.: .||:....:....|..:|:.:.||:|||:|||...|...:..:::
  Rat   127 VYDTPGSSIVTEFNLVCGD-AWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVS 190

  Fly   204 GVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG-EALLGL 267
            ||..|::.||.|.|.|.||..:.:.|.:...:.:..|.||...|..::|:....:.|| ..|.|:
  Rat   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGV 255

  Fly   268 SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR----DISV 328
            :..:||||.||||:|:|..:.:.|:|.||||.||||::.|..:|..|:.:.|:.|.:    |:.:
  Rat   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKM 320

  Fly   329 ELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYY 393
            ..:              |:|.        .:|...:..::.|:..|.....||:.:|...|::|.
  Rat   321 LCL--------------EEDA--------SEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQ 363

  Fly   394 GLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQ 458
            ||.::..:...|.||:|....|||.|...:..:.:.|.||...::.|.|:....|:...|:.
  Rat   364 GLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIP--- 425

  Fly   459 GDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFA 523
                         |.   .:||.|||..:|::|.|....::....||:.||.||:.|:.|.|...
  Rat   426 -------------HE---LHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALC 474

  Fly   524 RFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582
            ..|.:..||:.. |...:..|||:|||.|.|.||.::||||||....||:|:|||..||:
  Rat   475 DLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/562 (29%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	164/562 (29%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)