DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	607	Identity:	168/607 - (27%)
Similarity:	278/607 - (45%)	Gaps:	124/607 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQ--RRNYLLICLPVLFAAANSLSYV----FTAGSPTYRCYVPECDKLVDAE 73
            |.|:|..:|..||||  :..:||||..:      ::.:|    |||.:..:||:|    .::|.:
Mouse     3 FQDLLNLVGSHGRFQILQMAFLLICNVI------TMPHVILENFTAANLGHRCWV----HIIDND 57

  Fly    74 YGAN----------WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENF 128
            ..:|          .:.|::|...:.|    |..|.|||         ...|.....:..|:...
Mouse    58 TNSNNNSGILSQDDLLRISIPLDSNLR----PEKCRRFV---------QPQWHLLQFNGSFSNMT 109

  Fly   129 TTETERC-NQFVYGSSERTI----VQQWGLQC-PENLWKLA-FVGTIHFAGLVVGTALSGYLADR 186
            ..:||.| :.:||  .:||.    |.:|.|.| .:.|..:| |:..|   |::.|..:.|:|:|:
Mouse   110 EPDTEPCMDGWVY--DQRTFLSTTVTEWNLVCGSQELNSVAKFIFLI---GVLAGHFVGGHLSDK 169

  Fly   187 YGRKHIFLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPL---AFIIGVEMVGPRKRE 248
            :|||.:|...::.||:||...||:   .:|..:.||..:....:.|:   :.::.:|...|:.:.
Mouse   170 FGRKLLFRCALLQMAITGTCTALA---PTFFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPKTQA 231

  Fly   249 M-SSIVLNYFYAVGEALLGLSVFLPDWRQLQLALSVP--PLICVAYFWLVPESVRWLLARNRREQ 310
            : :::.::..:..|..|.||:....:|..||||:|||  .|:.....||. ||.|||:..|:.::
Mouse   232 LVTTLSMSSHHFGGLILAGLAFAFQNWHHLQLAISVPIFVLLIPTSRWLT-ESARWLIVTNKPQK 295

  Fly   311 AGVIIRRAAKVNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARS---- 371
            |...:|:.|..|          ..|..| |..|     :|....:.||:   :|:.....|
Mouse   296 ALQELRKVASKN----------GIKNSE-DVLT-----MEVVRTIMKDE---IAIPRTKPSLRDL 341

  Fly   372 -HI--LMGRYAILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGR 433
             |:  |..|..:|.|:..:......|:::|...|.||.:|..:|.....||..:|....|...||
Mouse   342 FHMPNLRKRLCLLCLLRFLQISPTVGINMNLQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGR 406

  Fly   434 RVA-----LSGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGIT 493
            |::     |...:.|.||..|.....||                       |||.:.|.|
Mouse   407 RISQLLPCLLFGIFLLSIVSVPQEMQTL-----------------------LVVLITLAG----- 443

  Fly   494 SSFAVIYT----FTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLV 554
            .|.|:||.    :::|:||||||:..:||:......||.|:|.:.:|..|...||.:::|.||::
Mouse   444 GSSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASLPWIIYGVLSIL 508

  Fly   555 AGLLSLLLPETFNRKLPDTVEE 576
            .|||.|:||||.|:.|||::::
Mouse   509 GGLLPLILPETKNQPLPDSIQD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/594 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	107/397 (27%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	123/452 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843926
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940