DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and SV2C

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	599	Identity:	123/599 - (20%)
Similarity:	198/599 - (33%)	Gaps:	222/599 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 FVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMAL 202
            ||..|:|..:       |..|... .::|:|.:.|::||....|.|||:.|||...|.|   |::
Human   174 FVLPSAETDL-------CIPNSGS-GWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLIC---MSV 227

  Fly   203 TGVAQALS---WDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG--- 261
            .|....||   ..|..|||..||:..|..|..|..|....|::...||......|..|:.:|
Human   228 NGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIY 292

  Fly   262 -EAL-------------LGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAG 312
             .|:             :|.:.....||...:..::|.:..|.....:|||.|:||...:.::|.
Human   293 ASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357

  Fly   313 VIIRRAAKVNRRD-------ISVELMASFKQ----QELDAETGQ---------EDDVEGGLHVKK 357
            :|::.....|.|.       .:|..:.:.||    .|::::||.         ..::.|
Human   358 MILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYG------ 416

  Fly   358 DDKIWLAVKEV----ARSHILMGRYAILLLIWAVNAIVYYGLS----------------LNATSL 402
               |||.....    .|.:.:.     |.::|...:..|||||                |...::
Human   417 ---IWLTFMRCFNYPVRDNTIK-----LTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNV 473

  Fly   403 SGNKYLNFAL-----------------------------------VCLVE--------------- 417
            ..:||.||.:                                   .|..|
Human   474 ERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFI 538

  Fly   418 -------------------------------------------------------IPGYSLAWLF 427
                                                                   :||..::.|.
Human   539 DTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 603

  Fly   428 LRRFGRRVALSGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKL-- 490
            :.|.||...|.||::|..|:|....|.|            .||              .::|.|
Human   604 MDRIGRLTMLGGSMVLSGISCFFLWFGT------------SES--------------MMIGMLCL 642

  Fly   491 --GIT-SSFAVIYTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPFV-PLLASYYDPLPLLLFGTL 551
              |:| |::..:...|.|:.||..|:.|.|.::...:..|:|...: ..|.|....:|:||..|:
Human   643 YNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTV 707

  Fly   552 SLVAGLLSLLLPET 565
            .:..||:.|.||:|
Human   708 LVCGGLVGLCLPDT 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	123/599 (21%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	106/544 (19%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	123/599 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128
		MFS	155..719	CDD:119392	120/595 (20%)
		Pentapeptide_3	507..561	CDD:290309	2/53 (4%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		2/43 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910