DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	582	Identity:	156/582 - (26%)
Similarity:	276/582 - (47%)	Gaps:	75/582 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWV 79
            |.|::::||..||||..:.:.:.:....:|.::|...|||..|::||:||..|....::.|:..:
Mouse     3 FQDLIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNGSRIL 67

  Fly    80 S------IAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERC-NQ 137
            |      |::|...:.|    |..|.|::         ...|....|:..|......:||.| :.
Mouse    68 SQDDLLRISIPLDSNLR----PDKCRRYI---------QPQWHLLHLNGTFPTVTEPDTEPCVDG 119

  Fly   138 FVYGSSE--RTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFM 200
            :||..|.  .|.|.||.|.|...... :....|:..|:.:|..:.|:|:|::|||.||...::.|
Mouse   120 WVYDQSTFLSTTVTQWDLVCGSQALN-SVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKM 183

  Fly   201 ALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL 265
            |:|....|.:..::.:.....|:.:.:|.:...:.::.:|...|:.:.:...::.....||:.||
Mouse   184 AITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASGVGQTLL 248

  Fly   266 -GLSVFLPDWRQLQLALSVPP-LICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNR----- 323
             ||:....:|..||||||||. |:.:...|| .||.|||:..|:.:::...:::||.|||
Mouse   249 GGLAFAFRNWHHLQLALSVPMFLLLIPTRWL-SESARWLIMANKPQKSLKELKKAACVNRIKNSG 312

  Fly   324 RDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVN 388
            ..:::|::.:..::||:|...:...:                 ::.|:..|..|..:|..:..|:
Mouse   313 DALTLEVVKTIMKEELEAAQTKPSPL-----------------DLFRTPNLRKRICLLSFVRFVS 360

  Fly   389 AIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVA--LSGSLLLCSITCVAS 451
            .:...||.:|...||.|.:|...|..:|.||...|....:...|||:.  :..|:|..||..|
Mouse   361 VMSLLGLLINIQYLSNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAV-- 423

  Fly   452 GFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTF--TAEMMPTVIRSG 514
              |.|.|                   ...::.:||....|..||.::..|.  ..|::||:||:.
Mouse   424 --VFLPQ-------------------EMQILRVFLSTLGGAISSASITSTLVHANELVPTIIRAT 467

  Fly   515 GVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            .:||:......|..|:|.:.:|.:|...||.:::|.|..:.||::||||||.|:.|||::::
Mouse   468 ALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGILPFLGGLVALLLPETKNQPLPDSIQD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	152/569 (27%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	96/385 (25%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	151/568 (27%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940