DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_033229.3	Gene:	Slc22a12 / 20521	MGIID:	1195269	Length:	553	Species:	Mus musculus

Alignment Length:	577	Identity:	159/577 - (27%)
Similarity:	269/577 - (46%)	Gaps:	65/577 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDK-----LVDAEY 74
            |.::|..:|..||||....:.:..|:|:....::...|:|..|.:||:||..|.     .:..:.
Mouse     3 FPELLDRVGGLGRFQLFQTVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPGDL 67

  Fly    75 GAN-WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ- 137
            |.: .:::::|....::    |..|.||......|..|:...:.|.         ...||.|..
Mouse    68 GPDVLLAVSIPPGPDQQ----PHQCLRFRQPQWQLTESNATATNWS---------DAATEPCEDG 119

  Fly   138 FVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFM 200
            :||..|  ..|||..|.|.|.....: ....:|..||::||.|:.|:.:||:||:.:..:..:.:
Mouse   120 WVYDHSTFRSTIVTTWDLVCNSQALR-PMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLV 183

  Fly   201 ALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL 265
            :::|.|.|....:..:..|..|.|...:||......:.:|....:...:...:....::.|:.|.
Mouse   184 SVSGTAAAFMPTFPLYCLFRFLLASAVAGVMMNTASLLMEWTSAQGSPLVMTLNALGFSFGQVLT 248

  Fly   266 GLSVF-LPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR----- 324
            |...: :..||.||||:|.|..:...|.|.:|||.|||:...:.:|....::|.|.||||
Mouse   249 GSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGKLDQGLQELQRVAAVNRRKAEGD 313

  Fly   325 DISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNA 389
            .:::|::.|..::|                 ...||...::..:..:..|..|..|.:|.|....
Mouse   314 TLTMEVLRSAMEEE-----------------PSRDKAGASLGTLLHTPGLRHRTIISMLCWFAFG 361

  Fly   390 IVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFV 454
            ..:|||:|:..:|..|.:|..||:.:|:.|..:.:.|.:.|.|||:.....|:|..: |:.|..:
Mouse   362 FTFYGLALDLQALGSNIFLLQALIGIVDFPVKTGSLLLISRLGRRLCQVSFLVLPGL-CILSNIL 425

  Fly   455 TLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVM 519
                   :|...||           |...|.::|...:..:|..|..|::|:.|||||...||:.
Mouse   426 -------VPHGMGV-----------LRSALAVLGLGCLGGAFTCITIFSSELFPTVIRMTAVGLC 472

  Fly   520 STFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            ...||.||||.|.|.||..|...:|||::|.:.:::||.:||||||.|..||||:::
Mouse   473 QVAARGGAMLGPLVRLLGVYGSWMPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	155/564 (27%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	100/380 (26%)
Slc22a12	NP_033229.3	2A0119	11..526	CDD:273328	155/564 (27%)
Slc22a12	NP_033229.3	MFS	147..516	CDD:119392	112/404 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960