DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	580	Identity:	189/580 - (32%)
Similarity:	290/580 - (50%)	Gaps:	65/580 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYR-CYVPECDKLV-------D 71
            ||..|.:.|||||||||.:||:||..:..|...:..||....|.|. |..|....|.       :
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    72 AEYGANWVSIAVPGSWSKRGHFTPSTCERFV--ANGDHLESSSDPWSAWPLDQCFAENFTTETER 134
            .|:......:.||.....:||     |.|::  |.....|.|.||.:|:|       |.:.....
Mouse    69 EEWNLTTPELHVPAERRGQGH-----CHRYLLEATNTSSELSCDPLTAFP-------NRSAPLVS 121

  Fly   135 CN-QFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIV 198
            |: .:.|..:..|||.|:.|.| .|.|.|.....|...|.:.|....||.||||||..|:|....
Mouse   122 CSGDWRYVETHSTIVSQFDLVC-SNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLISCF 185

  Fly   199 FMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEA 263
            .:.:|||..|.:.::..|:.|..|..|...|.:...|:|..|:||.::|.:..||:..|:.:|..
Mouse   186 GVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGII 250

  Fly   264 LL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDIS 327
            :| |::.|.|.|:.:|||:|:|..:.:.|:|:||||.|||:.|.:.|:|..|:||.||.|.:.:|
Mouse   251 ILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLS 315

  Fly   328 VELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVY 392
                     ......|..:::|...           :..::.|:..:.....||:..|..:|:||
Mouse   316 ---------SNYSEITVTDEEVSNP-----------SCLDLVRTPQMRKCTLILMFAWFTSAVVY 360

  Fly   393 YGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLA 457
            .||.:....:.||.|::|.:..|||:||..|..|.:.|.|||:..:.|.::..::|:.:.|  |.
Mouse   361 QGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAF--LP 423

  Fly   458 QGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTF 522
            :|  ||               ||..|:..:|:||||.:|.::|...:|:.||.:|:.||.:.|..
Mouse   424 EG--IP---------------WLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGL 471

  Fly   523 ARFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALG 581
            ..||.::|||:.. ||:.:..|||::||.|:.|.|.|.:|||||....||:|||:...||
Mouse   472 CDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	181/562 (32%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	118/375 (31%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	181/562 (32%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	131/406 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S3851
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810