DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus

Alignment Length:	583	Identity:	171/583 - (29%)
Similarity:	269/583 - (46%)	Gaps:	79/583 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDILVEIGEFGRFQRRNYLLICL------PVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEY 74
            ||||..||||..||::.:.|:.|      |:.      :..||...:|.:.|..|   .:.:...
Mouse     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPIY------VGIVFLGFTPNHHCRSP---GVAELSQ 60

  Fly    75 GANW-----VSIAVPGSWSKRGHFTPSTCERFVANG--------DHLESSSDPWSAWPLDQCFAE 126
            ...|     ::..|||..|.......|.|.|:..:.        |.|.|.:...|..||..|.
Mouse    61 RCGWSPAEELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCE-- 123

  Fly   127 NFTTETERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKH 191
                     :.:||.:...:||.::.|.|..: |.|....::...|..:|....||||||:|||.
Mouse   124 ---------HGWVYDTPGSSIVTEFNLVCAHS-WMLDLFQSLVNVGFFIGAVGIGYLADRFGRKF 178

  Fly   192 IFLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNY 256
            ..|..|:..|::||..|:|.:|...|.|..|..:.:...:.:.:|:..|.||...|....|....
Mouse   179 CLLVTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQI 243

  Fly   257 FYAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAK 320
            .:.||..:| |::..||:||.||.|:::|....:.|||.:|||.|||:::|:..:|..||:..||
Mouse   244 AFTVGLLILAGVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAK 308

  Fly   321 VNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIW 385
            .|.:.:.|.|      |.|.|      |.:.|:.:.......:...:: |.|.|     ||:..|
Mouse   309 KNGKSVPVSL------QSLTA------DEDTGMKLNPSFLDLVRTPQI-RKHTL-----ILMYNW 355

  Fly   386 AVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVA 450
            ..::::|.||.::......|.||:|....|||.|...:..|.:.|.|||...:.|.::....|:|
Mouse   356 FTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLA 420

  Fly   451 SGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGG 515
            |.|:.                   ....||.:|:..:|::|||.::.::....||:.||.||:..
Mouse   421 SVFIP-------------------DDLQWLKITVACLGRMGITIAYEMVCLVNAELYPTYIRNLA 466

  Fly   516 VGVMSTFARFGAMLAPF-VPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEA 577
            |.|.|:....|.::.|| |..|...:...||::|..:.||||.|.||||||..:.||:|:|:|
Mouse   467 VLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGGLVLLLPETKGKALPETIEDA 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	163/570 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	111/376 (30%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	163/570 (29%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	119/404 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930