DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and K09E9.1

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001368581.1	Gene:	K09E9.1 / 181654	WormBaseID:	WBGene00010724	Length:	518	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	129/579 - (22%)
Similarity:	233/579 - (40%)	Gaps:	138/579 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWVSIAVPGSWS 88
            :||.::.|..:|..|..:..||..|...|...||.:      ||.:.:.|.           ||.
Worm    52 DFGYYEIRLLVLTQLGYIPVAAAMLMTAFMEPSPEW------CDTVRETEQ-----------SWK 99

  Fly    89 KRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQFVYGSSERTIVQQWGL 153
                ..|:                                       |:|...|.||      |.
Worm   100 ----LNPN---------------------------------------NEFYSLSVER------GF 115

  Fly   154 QCPENL-WKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTGV----AQALSWDY 213
            .|.:|. ...|.:.::...|.::|:.:.|:|:||.|||.::|.|::.:.:..:    :..|||..
Worm   116 ACQKNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMT 180

  Fly   214 ISFLFFALLNAVG--TSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALLGLSV-FLPDWR 275
            |:    |.|.|:|  ..|.....|:|..|.....|..:..:.|| .::|..|:..|:. :..:|.
Worm   181 IN----ATLAAMGFFCGGYMVTNFVILTEAFELPKSRLLVVSLN-GWSVSMAVTALAASYTLNWY 240

  Fly   276 QLQLALSVPPLICVAYFWLV--PESVRWLLARNRREQAGVIIRRAAKV-NRRDISVELMASFKQQ 337
            ......::.. .|:|...|.  .||.|||.|...:..|..|..:...: |.|||
Worm   241 AYHTIFAIVG-ACIAIISLATCSESCRWLSANGLQNDAKKIALQITLLNNNRDI----------- 293

  Fly   338 ELDAETGQEDDV-----------EGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIV 391
                   :|||:           ....|. .:.|.|   |.:.:|...:...|::...:..::||
Worm   294 -------EEDDISILSWHEILGFSAPTHT-DEKKTW---KTLFKSTRFLKPTAVMCYSFMASSIV 347

  Fly   392 YYGLSLNATSLSGNKYLNFALVCLVE-IPGYSLAWLFLRRF--GRRVALSGSLLLCSITCVASGF 453
            .:|...:...|.||:|.|..::.::: |.|::.  .||.||  .|.:|:| |:.||   |:|:..
Worm   348 SFGFYFSIDVLPGNRYYNMTIMGILKFILGFTP--FFLNRFLTKRAIAIS-SVGLC---CLAALM 406

  Fly   454 VTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGV 518
            :       :|.|     .:...|..|:::.|.|:...||..::.:.:.::||:.||.:||...||
Worm   407 I-------LPIQ-----YYDIQCMRWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGV 459

  Fly   519 MSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLV-AGLLSLLLPETFNRKLPDTVEE 576
            .:...|.|:::||.:..|.::...:|..:|..|..: ..::.:.||:..::...:..:|
Worm   460 CNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFIQLVVIVIFLPDDSDKDANEMNDE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	128/574 (22%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	98/399 (25%)
K09E9.1	NP_001368581.1	MFS	98..505	CDD:421695	111/501 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010