DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and oct-2

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_509899.3	Gene:	oct-2 / 181325	WormBaseID:	WBGene00003843	Length:	757	Species:	Caenorhabditis elegans

Alignment Length:	605	Identity:	174/605 - (28%)
Similarity:	276/605 - (45%)	Gaps:	90/605 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPEC-DKLVDAEYG- 75
            :||:.||..||....:|...||:|.:..:..|..:||.|:....|.:.|.:|.. ::...||.|
Worm   154 IDFEGILQLIGGCSYWQIIVYLIISVQQVPHAMFNLSVVYMMYQPDHWCKIPFFNEESFSAELGY 218

  Fly    76 ANWV-------SIAVPGSWSK-RGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTET 132
            .|:.       :||.|.:::| |.......|..|..:..|::.|  ||:     |....|.|.:.
Worm   219 TNYTWDQVLNSTIAFPRTFNKQRNELHHDQCHYFERDYVHIKLS--PWA-----QVKDMNATGKI 276

  Fly   133 ERCNQFVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLF 195
            .||.::.|.:|  :||||.:|...| :|.|..|.|...:..|.:||..:.|:::||||||.....
Worm   277 NRCKEWEYDTSVMDRTIVTEWNRVC-DNNWSRAHVHMSYSLGYLVGCFVGGFISDRYGRKTAITG 340

  Fly   196 CIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAV 260
            ..:...|.|.....|.::..||....|.|.........|:::.:|:.|.:.|.:...::...:|.
Worm   341 FGILTMLFGFLLTYSKEFEIFLVVRFLLAATNEAADLAAYVLCMEVTGTKYRSIVGSLIQAPWAC 405

  Fly   261 GEALLGLSVFL-PDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR 324
            |.|.|.|..:| ..|..:.|...:..:|.:...:.:|||.|||:..|:.:||..|||.|...|:.
Worm   406 GYAFLALIAYLTKSWTMIHLICVLLHIISLMLLYFLPESPRWLILNNKTKQAEKIIREACHYNKS 470

  Fly   325 DISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKE------VARSHILMGRYAILLL 383
            .:..:|                     ||....:.|.|:...|      :.||..|..|..:|.:
Worm   471 RLPSDL---------------------GLVRHAEKKKWMKHNEKPSYFHLFRSSELRFRNVVLFI 514

  Fly   384 IWAVNAIVYYGLSLNATSLS--------GNKYLNFALVCLVEIPGYSLAW-LFLRRFGRRVAL-- 437
            :|...|:||||:.:..:..|        ||.:||.|:...:|:|  :|.: :||.|.||:.:.
Worm   515 VWIATALVYYGMVIALSDQSSPGRRVFDGNFFLNNAMAGAIELP--TLVFCVFLLRMGRKRSQML 577

  Fly   438 ----SGSLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAV 498
                ||..||.|:..|.....|||                        :...|:.|..|..||.:
Worm   578 VLFGSGLFLLTSVVMVYRKQSTLA------------------------LIFMLLSKACIQGSFNI 618

  Fly   499 IYTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPL-PLLLFGTLSLVAGLLSLLL 562
            :|.||:|:.|||:|:..||:.|..||.||..:.::.:|:....|| |:.:|...||:||.|.|||
Worm   619 LYIFTSELNPTVVRNSAVGISSMVARMGAGASGYIAILSDVTMPLVPMTIFACFSLLAGCLVLLL 683

  Fly   563 PETFNRKLPDTVEEAIALGK 582
            |||....||||:.:::.:.|
Worm   684 PETQGLPLPDTILDSVQMVK 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	166/584 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	108/396 (27%)
oct-2	NP_509899.3	MFS_SLC22	281..673	CDD:340875	121/439 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850