DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a16

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_002936981.2	Gene:	slc22a16 / 100488673	XenbaseID:	XB-GENE-961385	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	169/586 - (28%)
Similarity:	272/586 - (46%)	Gaps:	84/586 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWVSIAVPGS 86
            :|.|||||...|.......:....:.|:.||.|.:|.:.|..||           |..|:.:|.:
Frog     8 VGHFGRFQALIYFSSAFQAISCGIHYLASVFIAITPKFICRAPE-----------NISSVLLPNA 61

  Fly    87 WSKRGH-----FTPSTCERFVANGDHLESSSDPWSAWPLDQCF---AEN--FTTETERCNQFVYG 141
            .:.|..     :||.         |:|....:....|.|:||.   .||  :.|.:...|:.::.
Frog    62 STLRLEDVWELWTPK---------DYLVVKQENGDIWELNQCSRFKRENTSYLTYSYDGNKTLFS 117

  Fly   142 SS----------ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFC 196
            .|          |.:||..|.|.| |..|....:......|:::|..:.|.:|||.||:.|....
Frog   118 CSNGYYYDNTNLESSIVTDWHLVC-EREWLAKLIQPTFMFGVLIGAVIFGDIADRVGRRLILWLT 181

  Fly   197 IVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG 261
            .....|.|:|.|.::||.||:....|.|:.:||.|.:.|:...|.||.:.|..:|:.::.|:|||
Frog   182 STGQFLFGIAVAFTFDYYSFVIVRFLLAMVSSGYYVVVFVYVTEYVGIKARSWASMHVHAFFAVG 246

  Fly   262 EALLGLSVFL-PDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRD 325
            ..::.|..|| ..|...|:.||:..|..|...|::||:..||.::.:.::...:|....|.|:
Frog   247 VMIVSLVGFLVRTWWMYQIILSLTTLPFVLCCWMLPETPFWLYSQGKHKEVEKLIGTIEKWNK-- 309

  Fly   326 ISV-----ELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIW 385
            ||.     ||.:..:.|:.:.:|           :||.     :|.::..:.....|...:.|||
Frog   310 ISTPCKLSELCSVQETQKTEMDT-----------LKKH-----SVLDLFYNWSFARRTVTVWLIW 358

  Fly   386 AVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVA 450
            ...::.||..:||:.:|.||:|||..|...||||.|.:|...:.:.|||..|:..|:|.::.|
Frog   359 FTGSLGYYVFALNSVNLGGNEYLNLFLTSAVEIPSYIVACFGMDKIGRRNTLAPFLILSAVIC-- 421

  Fly   451 SGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGG 515
             |.:.|...|           ||     .:.:.:.:.||..|..:|.:||.:|||:.||::||..
Frog   422 -GIIMLIPQD-----------HS-----TVTIAMSMGGKFSIAVAFGLIYLYTAELYPTIVRSLA 469

  Fly   516 VGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIAL 580
            ||..|...|.|:::|||...|...:..:|.:|.|.::.:.|:|:|.||||....|..|:|||..:
Frog   470 VGSGSMMCRIGSVVAPFCVYLTDVWIFMPQMLVGIMAFLTGVLTLKLPETLGVPLTSTIEEAAEM 534

  Fly   581 G 581
            |
Frog   535 G 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/575 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	112/380 (29%)
slc22a16	XP_002936981.2	MFS_SLC22A16_CT2	111..517	CDD:340933	129/443 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010