DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a2

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	582	Identity:	179/582 - (30%)
Similarity:	281/582 - (48%)	Gaps:	74/582 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLIC-LPVLFAAANSLSYVFTAGSPTYRCY---VPECDKLVDAEYG 75
            ||::|..||||..||::.::|:| :.|:|:.. .:..||....|.|||.   :||...  :.|:.
Frog     4 FDELLEHIGEFDAFQKQIFILLCFISVVFSPI-YVGIVFLGFVPDYRCVSAGIPEPSN--ECEWT 65

  Fly    76 ANWVSIAVPGSWSKRGHFTPSTCERFVA--NGDHL---ESSSDPWSAWPLDQCFAENFTTETERC 135
            .|:.     |..........|.|.::..  |...|   .||.:..|..|:..|           .
Frog    66 LNYT-----GPNGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITNC-----------K 114

  Fly   136 NQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFM 200
            :.:.|.::..::|.::.|.|.:: |||.|..:....|..:|..:|||:|||:|||...:..|:..
Frog   115 DGWDYNTTGSSLVTEFNLVCGDS-WKLDFFQSCVNIGFFIGGLISGYIADRFGRKPFLISSILIT 178

  Fly   201 ALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL 265
            .:.|:..|.:.:|...:.|..:....:.|.:...:|:..|.||...|....||....:.||..||
Frog   179 GIFGILMAFAPNYPLVVTFRFIQGFVSKGCWLSGYILVAEFVGLEHRRTVGIVYQAAFTVGLLLL 243

  Fly   266 -GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR---DI 326
             |::..||.||.||:.:::|....:||:|.||||.|||:::||:.:|..||...||.|.:   |.
Frog   244 SGVAYVLPHWRWLQMTVTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVPDF 308

  Fly   327 SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIV 391
            ...|.|       |.|.| |..|...|.:.:..:|        |.|.|     ||:.||...|:|
Frog   309 LESLTA-------DEEAG-EKQVPSFLDLVRTPQI--------RKHTL-----ILMYIWFTCAVV 352

  Fly   392 YYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTL 456
            |.|..::..|.:.|.|.:|.:..|||.|...|..:.:.|.|||.......::..|||:.:.|:.
Frog   353 YQGSIMHMGSTAENIYFDFFISALVEFPSAILIIVTVDRVGRRYPWLVCCIITGITCLITAFIP- 416

  Fly   457 AQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMST 521
                           |.:|   ||::||..|.::|||.|:.::....||:.||.||:.|:.|.|:
Frog   417 ---------------HGYS---WLIITLSCVSRMGITVSYEMVCLVNAELYPTFIRNLGIMVCSS 463

  Fly   522 FARFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582
            ....|.::.||:.. ||:.:..|||::|..|:.|:|:|...||||..|.||:|:|||..|.|
Frog   464 MCDLGGVITPFIVYRLAAIWQELPLIVFAVLATVSGILVYFLPETKGRALPETIEEAENLHK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	169/563 (30%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	118/378 (31%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	169/563 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010