DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4630 and slc22a6

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	582	Identity:	164/582 - (28%)
Similarity:	275/582 - (47%)	Gaps:	83/582 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWV 79
            |.:||..||..||:|..:.:|:.|||...|:::|...|||..|.:||.:.  ....:..:...|:
Frog     3 FQEILESIGGMGRYQVIHVVLLSLPVFMLASHNLMQNFTAAIPRHRCQIN--GSFEETNFTGPWL 65

  Fly    80 SIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFT-----TETERC-NQF 138
            ...||  ....|.|  |.|.|:.....||               ..:|||     .|||.| :.:
Frog    66 RALVP--MKPTGEF--SKCLRYTTPQYHL---------------LMDNFTQNVDELETETCVDGW 111

  Fly   139 VYGSSE--RTIVQQWGLQCPENLWKLAFVG-TIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFM 200
            ||..||  .||:.||.|.|  |..::..|. :|:.||::||:.:.|.|:|::||:.:.::..:.|
Frog   112 VYDHSEFASTIITQWDLVC--NHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQM 174

  Fly   201 ALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGE-AL 264
            ::||:..|.|.:||.:..|..|.....||:...::.:.||.:....|..:|....|.|.:|: .|
Frog   175 SVTGICAAFSPNYIWYCIFRFLTGTALSGIVLNSYSLIVEWIPTGNRAFTSTATGYCYTMGQLVL 239

  Fly   265 LGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR----- 324
            :||:..:.||..||||.|:|......|.|.:|||.|||:...:.|.|...:::.||:|.:
Frog   240 VGLAFMIRDWHWLQLAASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGE 304

  Fly   325 DISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNA 389
            .::||::.|..|:|:.|.....                .:|.::.|:.::......:...|...:
Frog   305 KLTVEVLKSSMQREISASKHST----------------YSVLDLVRTPVVRRISFCISCTWFSTS 353

  Fly   390 IVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSIT-----CV 449
            ..||||:|:..|...:.|:...:...|:||....::..:...||||..:.:|:|..|.     ||
Frog   354 FAYYGLALDLQSFGVSIYIIQIIFGTVDIPAKFFSYFVMTYIGRRVLQALTLILAGIAILVNICV 418

  Fly   450 ASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSG 514
            ...:.|:.                        .::.:.||..:.:||..::.:|.|:.|||||..
Frog   419 PQDYQTVR------------------------TSMAVFGKGCLAASFNCLFLYTGELYPTVIRQS 459

  Fly   515 GVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            |:|:.:..||.|.::||...:....|..|||::||.|.:::|:....||||....||:|:|:
Frog   460 GMGLGTMMARLGGIIAPLAQMTGDIYHSLPLIIFGCLPILSGIAGCFLPETLGVPLPETIED 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/569 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	101/386 (26%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	123/447 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110