DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4630 and si:dkey-166k12.1

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_001341287.1	Gene:	si:dkey-166k12.1 / 100001249	ZFINID:	ZDB-GENE-120215-78	Length:	537	Species:	Danio rerio

Alignment Length:	571	Identity:	186/571 - (32%)
Similarity:	294/571 - (51%)	Gaps:	77/571 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN 77
            ::||.:|..||.||::|:..|:.||||.:|...:.::.|||..:|.:||
Zfish     1 MNFDQLLATIGGFGKYQKLLYVWICLPQIFLGFHMMASVFTGATPPHRC---------------- 49

  Fly    78 WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCN---QFV 139
                  .||.|....:|      |.:|..|:..|....:.: .|.|.|.:....:.|.|   .:|
Zfish    50 ------RGSTSGMEDWT------FTSNLSHVNLSISRLAGF-ADACTAASGVNRSARTNCETGWV 101

  Fly   140 YGSS--ERTIVQQWGLQCPENLWKLAFVG-TIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMA 201
            |...  :.|.|.:|.|.|.:.  .|:.:| :|:..||:||..:.|.:||||||:...|..:....
Zfish   102 YSHEVFQSTTVTEWDLVCDKR--GLSSLGSSIYMLGLLVGAVVFGAMADRYGRRFAMLVSLALQT 164

  Fly   202 LTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL- 265
            :.|||.|.:.::..::....:..:..|||...||::|.|....::|.::.|..:||:..|..||
Zfish   165 VFGVAAAFAPNFPVYVGLRFIIGMTVSGVIINAFVLGTEWTCTQRRMLAGIFTDYFFGFGYMLLA 229

  Fly   266 GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVEL 330
            |::..:.|||:||||:|.|..:.:.|.|::|.|.||||..||:|:|..::|:||.||.|    .|
Zfish   230 GVAFLIRDWRKLQLAISAPGFLFIFYIWVLPHSARWLLVNNRKEEAIDLLRKAASVNGR----TL 290

  Fly   331 MASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395
            ..:.:.:..::..|:..               ..|.::.|:..:..|..||..||.||.:|||||
Zfish   291 PPTVQVERYESPQGRSK---------------YTVVDLLRTPQMRKRALILFYIWFVNVLVYYGL 340

  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460
            ||..:.|..:.||...:..|||||..:|. |.|....|::.||..|::....|:    :||.
Zfish   341 SLGVSDLGADLYLTQFMFGLVEIPARTLV-LVLLPCSRKIPLSVFLVVGGGACL----LTLT--- 397

  Fly   461 WIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFARF 525
             :|    .:|.|       :...|.:|||.|||:|||:||.::||:.|||:|..|:||.|.|||.
Zfish   398 -LP----ADSAH-------VRTALAMVGKFGITASFAIIYVYSAELFPTVLRQTGIGVSSMFARM 450

  Fly   526 GAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            |.:|||.:.||..:...:|:|:||:..|:|..|:|.||||..:.|||::.:
Zfish   451 GGVLAPLINLLGRHTPVVPMLIFGSTPLLAAALALALPETARQPLPDSIHD 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	181/556 (33%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	129/376 (34%)
si:dkey-166k12.1	XP_001341287.1	2A0119	11..497	CDD:273328	180/555 (32%)
si:dkey-166k12.1	XP_001341287.1	MFS	123..458	CDD:119392	129/373 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.030