DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a5

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	578	Identity:	180/578 - (31%)
Similarity:	287/578 - (49%)	Gaps:	75/578 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW 78
            ::|:....:|:.|.|..|.:.|:.|..:....:.|..||.|.||.:||       .||.....:|
Zfish     3 NYDEDTAFLGQTGPFFIRLFCLLNLIYISTGLHGLYIVFVAASPAHRC-------RVDVNLTEDW 60

  Fly    79 VSIAVPGSWSKRGHFTPSTCERFVANGDHLES----SSDPWSAWPLDQCFAENFT-TETERCNQ- 137
            :..:.|......|....|.|.|:     .|::    |...:|...:      |.| ...|||..
Zfish    61 LEASAPTETLSNGDLQVSQCWRY-----SLQTLTNLSGQGYSPGQI------NITDIPRERCEDG 114

  Fly   138 FVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFM 200
            :||.:.  ..|||.:|.|.| ::.|::....:..:.|.::|:.:||.|:||:|||.:....:...
Zfish   115 WVYSADVYHSTIVSEWDLVC-DSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLFGSLAAE 178

  Fly   201 ALTGVAQAL--SWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYF--YAVG 261
            ||...||:.  ||.....|:| .:.|...| :|..||::|.|::....|.:.: .|..|  |.||
Zfish   179 ALLMFAQSFSPSWLIFCVLYF-FIGAFQIS-LYITAFVLGNEVLSGSLRVLFT-TLGAFLHYCVG 240

  Fly   262 EALLGLSVF-LPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRD 325
            ..||....| :..||.|...||...::.:..:||:|||.||||::...:::..|:|.||:.||..
Zfish   241 YMLLPWVAFAIRHWRTLLRVLSGLTVVYIPLWWLIPESPRWLLSQGHVQESEAILRDAARKNRVP 305

  Fly   326 ISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAI 390
             :.|::  |||.::.....|:..             :.|:..:..|:|....:..|||..|:| |
Zfish   306 -APEVI--FKQSQIKEAAFQKSK-------------YSALDVLRTSNIRRTTFMCLLLWMAIN-I 353

  Fly   391 VYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVT 455
            .|:|||||.|:|||:.:||..|..:.|:|.|.::...|:...||..||..|:      :..||:.
Zfish   354 GYFGLSLNTTNLSGDPFLNCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLV------IGGGFLL 412

  Fly   456 LAQGDWIP--CQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGV 518
            |.|  .||  .||             |.:.|.:.||.|.|.||.|:|.:|||:.|||:|:.|:|:
Zfish   413 LVQ--LIPDRLQT-------------LALALEMAGKFGFTMSFTVVYIYTAELYPTVLRNLGMGM 462

  Fly   519 MSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            .|:.||.|::.||::..|.::...||.:|.|:|::.|.|.:|.|||||.:.||:.:|:
Zfish   463 CSSAARIGSITAPYIIFLGTFNRHLPYVLMGSLTITASLANLFLPETFGKVLPENLEQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	178/564 (32%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	124/381 (33%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	177/563 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020