DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AQP and AQP12B

DIOPT Version :9

Sequence 1:	NP_523728.1	Gene:	AQP / 36456	FlyBaseID:	FBgn0033807	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	XP_011509973.1	Gene:	AQP12B / 653437	HGNCID:	6096	Length:	544	Species:	Homo sapiens

Alignment Length:	265	Identity:	71/265 - (26%)
Similarity:	120/265 - (45%)	Gaps:	22/265 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGISALFMVGCCALAQIARVISRRLVTREGLVPILINEAIAAAELCACCFELIIV------ADNF 64
            |.:|..|......|.:.||..|:.|:. .|...:...||:.|.:|.||..|:..:      |.:|
Human     4 LNVSLSFFFATFTLCEAARRASKALLP-VGAYEVFAREAVGAVQLGACFLEMRTLVELGPWAGDF 67

  Fly    65 GVSMYAVCLFLLTIWWGRVWGDASACPYTHMEDVVEGRTSFKEMALRSWAELMGGCCVYRVVQVF 129
            |..:....||||.:..|.....|||.|...:::.:....|.....|:..|:.:|......:.::.
Human    68 GPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLC 132

  Fly   130 WWLELAETH--RGRAFEACNADMQVSPYLGAVIEGVATLLCRLASKTISEKEPRFGSYIDSFIGT 192
            |..||::.|  :....::|::.::.|...||::|........|....:....|.:     |....
Human   133 WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAY-----SGPAV 192

  Fly   193 SLVVAVYAFNYVLLAAFNFSGGYFNPVLATALKWGCRGHTHLEHIIVYWIGACAGAV---LSIPV 254
            :|:|.|.|:     .|..|:..:|||.||.::.:.|.|||.||::.|||:|...|||   |::..
Human   193 ALLVTVTAY-----TAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGAVTACLTVDT 252

  Fly   255 FKVPA 259
            ..||:
Human   253 VPVPS 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AQP	NP_523728.1	None
AQP12B	XP_011509973.1	MIP	<89..248	CDD:294134	44/168 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158448
Domainoid	1	1.000	72	1.000	Domainoid score	I9326
eggNOG	1	0.900	-	-		E1_2A80J
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I5178
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1080106at2759
OrthoFinder	1	1.000	-	-		FOG0005875
OrthoInspector	1	1.000	-	-		otm41908
orthoMCL	1	0.900	-	-		OOG6_109463
Panther	1	1.100	-	-	O	PTHR21191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760