DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AQP and AQP12A

DIOPT Version :9

Sequence 1:	NP_523728.1	Gene:	AQP / 36456	FlyBaseID:	FBgn0033807	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_945349.1	Gene:	AQP12A / 375318	HGNCID:	19941	Length:	295	Species:	Homo sapiens

Alignment Length:	268	Identity:	71/268 - (26%)
Similarity:	122/268 - (45%)	Gaps:	23/268 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGISALFMVGCCALAQIARVISRRLVTREGLVPILINEAIAAAELCACCFELIIVADNFGVSMYA 70
            |.:|..|.....||.:.||..|:      .|:|:...| :.|.|......||...|.:||..:..
Human     4 LNVSLSFFFATFALCEAARRASK------ALLPVGAYE-VFAREAMRTLVELGPWAGDFGPDLLL 61

  Fly    71 VCLFLLTIWWGRVWGDASACPYTHMEDVVEGRTSFKEMALRSWAELMGGCCVYRVVQVFWWLELA 135
            ..||||.:..|.....|||.|...:::.:....|.....|:..|:.:|......::::.|..||:
Human    62 TLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLCWAWELS 126

  Fly   136 ETH--RGRAFEACNADMQVSPYLGAVIEGVATLLCRLASKTISEKEPRFGSYIDSFIGTSLVVAV 198
            :.|  :....::|::.::.|...||::|........|....:....|.:     |....:|:|.|
Human   127 DLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAY-----SGPAVALLVTV 186

  Fly   199 YAFNYVLLAAFNFSGGYFNPVLATALKWGCRGHTHLEHIIVYWIGACAGAVLSIPVF--KVPAV- 260
            .|:     .|..|:..:|||.||.::.:.|.|||.||::.|||:|...|.||::.:.  ::|.:
Human   187 TAY-----TAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLF 246

  Fly   261 -RRLLLGE 267
             |.|..|:
Human   247 QRNLFYGQ 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AQP	NP_523728.1	None
AQP12A	NP_945349.1	MIP	<77..239	CDD:294134	44/171 (26%)
		NPA 1	81..83		0/1 (0%)
		NPA 2	200..202		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..295
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158449
Domainoid	1	1.000	72	1.000	Domainoid score	I9326
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I5178
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1080106at2759
OrthoFinder	1	1.000	-	-		FOG0005875
OrthoInspector	1	1.000	-	-		otm41908
orthoMCL	1	0.900	-	-		OOG6_109463
Panther	1	1.100	-	-	O	PTHR21191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860