Protein Alignment FLASH and casp8ap2

DIOPT Version :10

• Sequence 1: NP_610845.1
• Gene: FLASH / 36455
• FlyBaseID: FBgn0033806
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001014356.2
• Gene: casp8ap2 / 541521
• ZFINID: ZDB-GENE-030826-8
• Length: 1995
• Species: Danio rerio
• Alignment Length: 1251
• Identity: 224/1251 - (17%)
• Similarity: 413/1251 - (33%)
• Gaps: 498/1251 - (39%)

  Fly    24 MDLEDQDAGGMKSNVKDKSMDLDIYH-----DLYDIEPAGSKKPDQMD----------RSLE-LD 72
            ||..|:    :..::.|||....::|     |:|    :|.:...:.|          |::| :|
Zfish     1 MDSMDE----LYGDIVDKSSGTPLHHSEDSVDIY----SGLENSPKCDGHRVNTILSPRTMESMD 57

  Fly    73 IYDDLDDFQKAEDRNT-----KELQAWEAKYEKALAEIEALKVENKALGKKIKTMEVNLQNLLDT 132
            ||:::...::.|...|     ::....:.:..:.|::::.|:.:|.:|..:...::.|:.:|:.|
Zfish    58 IYEEIIREEQEEKEATYNELKQKFDGAQKQVNELLSKLQLLQTKNSSLSSENILLKKNICSLIKT 122

  Fly   133 AKAEVKRKETLIAELRNEKDDVCF--------------------RRKRARAFDVPGAREPE---- 173
            |:.|:.||:..|:.|.|......:                    ........:..|||:.:
Zfish   123 ARMEIVRKDEEISRLSNRSGRGSYGHSFYQSQMGSASANTRHTLNNSTGSVLESRGARQEKVMDE 187

  Fly   174 -SKRPKEFQSTPID-------VRKYPET-NRNPFKTAAKDAAKDDARKMM--------------- 214
             :::.....||.|.       :::.|.| :.||.::..|.|||.| |:::
Zfish   188 VNQQTDRITSTSISASQPFEVLQRCPRTESENPLQSQNKSAAKTD-REILSIQPQQEYRPVPPCR 251

  Fly   215 TKKDDTTKVVSKDVERGVKSK------------------EDNKMATNKDDDK-----KSSSKDDA 256
            |.:..|......|:....|:|                  :|||...:..|||     |.:|||..
Zfish   252 TSESITNPTTLPDILNTSKTKNYKKRVPDETTDCQLSNLKDNKNCPSNQDDKLEKPQKCTSKDQM 316

  Fly   257 WKSRTRE-------DAKKSVQRSK----------------------------------------S 274
            ..|:.::       |..|.|:..|                                        |
Zfish   317 CNSKNKDVSPQSKADLSKPVRMEKELTKDNSVSSENRSQQLEVPVVLKSSEQLKSHSSQSHKSFS 381

  Fly   275 PRPEHSKT--------------------------------------------------------- 282
            ....||:|
Zfish   382 SASSHSRTLIKKAADTEVQSQGHMHKQNAERTSRETRQSGLSSTECTVVSEENHSQSHKGKKRDA 446

  Fly   283 ------------TDRKSTAQARRPDPHRSRSPKHNSR-----------RDHHRNQESSSRHAKRR 324
                        |:|:|:...|..| |..:.||.::|           |:...|:..|||..:||
Zfish   447 SGSERKEEKRSSTERRSSKTERSRD-HEQKRPKESNRSKRDEGNSCSSRERRSNRSESSRDHERR 510

  Fly   325 SQSASPSKIQLPR--------EKANAIITLTDD----ETNDQRSKS---PVP------------- 361
            |.....:|.|..|        :...|:.:...|    :.|.::|.|   .||
Zfish   511 STKGKDNKDQDKRSTKQVDGSDSRRAVSSPKHDSQRKDVNKEKSSSRLDEVPSKSKSSHRHDKSR 575

  Fly   362 --VTVKLVTESQPAEKVV--------SNRRDAALETN----------------ANSSKESK---- 396
              |.:|.:::|:.::|..        ..:|:..||.|                ..|||:.|
Zfish   576 RTVDLKYLSKSRNSDKTCLADKEIEKDRKRNGHLEENRVEKDGESKKLIKDDRKKSSKKHKTSRR 640

  Fly   397 -----------VETKDITQPT-NGLIAEPCIPKHEIIPGLSLINPESADFSKNEIKL-------- 441
                       :|:..:..|: ..:.:.||....:..|...|...|:.:.:.:.:|.
Zfish   641 CQDIENGQDMRLESVHLESPSVVSVSSSPCKTAEDYSPDRKLSFMETLNLTLSPLKKQKPSSAPK 705

  Fly   442 --------DPVILQDRTEDSGHQLLNKEPIPKVVVLEKCKNILAEDCPADEQP-LDKFKD----G 493
                    |.:....|..|||.:..         |:::.||........||.| |...:|    .
Zfish   706 EATGGISEDVIFHNSRCSDSGEEFF---------VIDELKNSQNSVEEMDEIPELTNAEDLTCSF 761

  Fly   494 KESEE--------TQAKLD-KKEPFAVE--------------TAVETPSKEESN----------D 525
            |:||.        |..||. :|...|::              .|:..||:|:.:          |
Zfish   762 KQSENALDMMTAVTSEKLSTEKIEIAIQNKNVTENQETVDEVAAIVNPSEEKKDTSLESKILDTD 826

  Fly   526 NIVLSKNTTSQADVCSQ-HDENDEAEI---------------------REPMDQVNSVVESDLGV 568
            :|.:...|....|..|| |.|:....|                     ..|...|:..::.||..
Zfish   827 SISVITLTKESPDFASQSHAEDSPGTIDNAVAVFNTSPAKPSEDAISDNVPQSIVDGCLQPDLFA 891

  Fly   569 RIIEDI--------RLPKMANI-----------------DHFAVKVDNHGEAPAAVTDSALNQEN 608
            .:.::.        .||...::                 :|.:..:::.|.     :||:::.|
Zfish   892 TVSKETSQKEFQGNTLPMSKDVLLESNEICQGAVSSSDKEHNSATINSSGN-----SDSSVSME- 950

  Fly   609 LATQDQKICAEMKDPTIFTTSDETPIKSATIL-YAKPDSTKLDHSDEHDEVILETAIDMLKKEQD 672
              .....|||::..|            |..|. :.:.||.:    |:.:..|.|. |.|::.:|
Zfish   951 --VSSSTICADLNGP------------SKVICDFEQVDSAE----DDREREIFEN-IKMMETQQ- 995

  Fly   673 AASTAESTYPKLRIAEDAIEMALEQLHQQSPD-------ETVVTSTSN--------RAPQTPKS- 721
               |:|:    |:|:|.:::..|...:.::|:       ||:..|.|:        :..|.|||
Zfish   996 ---TSEN----LKISETSLQSPLRSENTKAPNDGTSVEKETISFSQSSFLEPDSTEKEEQIPKSS 1053

  Fly   722 ------------LITI--LTQTPKQADPLRSQTKS-KTVSP---------MATPKKTATEKTPVK 762
                        ::|:  :...|:...||.|..:. |.|.|         .:..|..:|.....:
Zfish  1054 NSVLFCHDEDSMMLTLRNIRVIPEPISPLTSPVRQVKKVQPPLAEKQPHVKSLSKDLSTVTAGSE 1118

  Fly   763 KRKVNMDSSPQVPAHDVTIDETLGACSLQDESSTVTKRCSLGHTDYQYEQIKD-EVILRVKRRGR 826
            |.|||||.:.:..:.|.::     .||    |..|||. :|..:..:.::::| |::...:..|
Zfish  1119 KDKVNMDMNKENKSPDSSV-----TCS----SYNVTKD-ALSASGNEEDELEDGEIVSESEEEG- 1172

  Fly   827 RRKPTPMEIPTTAADK 842
               |..::.|....||
Zfish  1173 ---PLFIQTPPREKDK 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLASH	NP_610845.1	None
casp8ap2	NP_001014356.2	PTZ00121	<392..>675	CDD:173412	43/283 (15%)
		CASP8AP2	1927..1991	CDD:213401