Protein Alignment FLASH and Casp8ap2

DIOPT Version :10

• Sequence 1: NP_610845.1
• Gene: FLASH / 36455
• FlyBaseID: FBgn0033806
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001101391.1
• Gene: Casp8ap2 / 313128
• RGDID: 1305771
• Length: 1962
• Species: Rattus norvegicus
• Alignment Length: 1029
• Identity: 199/1029 - (19%)
• Similarity: 348/1029 - (33%)
• Gaps: 337/1029 - (32%)

  Fly    51 LYDIEPAGSKKPDQMDRSLELDIYDDLD------------DFQKA----EDRNTKELQAWEAKYE 99
            |:|:.||...|.:...   .||||..||            .|:..    |:..|:|..|.||.|.
  Rat    13 LFDVCPASPLKNNDEG---SLDIYAGLDSTVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYS 74

  Fly   100 KALAEIEALKVENKALGKK---IKTMEVNLQN-----------LLDTAKAEVKRKETLIAEL--- 147
            ....|....:.:.|.|.|:   |:|..:||:|           |:.||:.|:.||:..|..|
  Rat    75 DLQIEYGKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQR 139

  Fly   148 -------RNE------KD--------DVCFRRKRARAFDV-----PGAREP----ESKRPKEFQS 182
                   ||.      ||        |.|.:.......||     |...:|    |.|...|.|:
  Rat   140 LSEFPHFRNNHKTARTKDSRSKSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQN 204

  Fly   183 T---PIDVRKYPETN---RNPFKTAAKDAAKDDAR--------KMMTKKDDTTKVVSKDVERG-- 231
            :   ...:.|:...|   |:|::.:..::.:|:.|        :.....|.|.|.::.....|
  Rat   205 SLHLSTGIEKHCTNNVWSRSPYQVSEGNSNEDNRRGRNGVRHSQGSRGTDRTQKDLNSSCNDGEP 269

  Fly   232 ------------------VKSKEDNKMATNKDD---DKKSSSKDDAWKSRTREDA---------- 265
                              .:::.:||::..|..   ..||.....:|:..|..:.
  Rat   270 RDKEAASRLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKETSRERPHTRVEPQND 334

  Fly   266 --------------KKSVQ-RSKSPR-----------------------PEHSKTTDRKSTAQAR 292
                          :|.:| :.|:.|                       |.|||...:.......
  Rat   335 KNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMKYYGFNKY 399

  Fly   293 RPDPHRSRSPKHNSRRDH----HRNQE---SSSRHAKRRSQSASPSKIQLPREKANAIITL---- 346
            .|:..|.|   .:.:||.    |..|:   |||..:.|.|:.....::.:..:..|.....
  Rat   400 HPEERRGR---EDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQWENTPFKAERHR 461

  Fly   347 TDDETNDQRSKSPVPVTVKLVTESQPAEKVVSNRRDAALETNANSSKESK-------VETKDITQ 404
            |:|....:|........||...:| |.|.:....:|....| ||..::::       |.|.::::
  Rat   462 TEDRRKRERENKEESRHVKSDKKS-PPEHLQRTHKDTKKST-ANGKRQTEQKHGKGPVSTSELSK 524

  Fly   405 PTNGLIAEPCIPKHEIIPG------LSLINPESADFSKNEIKLDPVILQDRTEDSGHQLLNKEPI 463
            .|:.   ..|..|.|..|.      |.|...|..:.:.:..|..||     .:|:.||::.   :
  Rat   525 GTDN---RECTMKVENGPNEAKGKDLKLSFMEKLNLTLSPAKKQPV-----CQDNEHQIIG---V 578

  Fly   464 PKVVVLEKCKNILAEDCPA---DEQPLDKFK--------DGKESEETQAKL-DKKEPFAVETAVE 516
            ||               |:   |.|.|:|.:        ..::.||.:::| :.||..:..:...
  Rat   579 PK---------------PSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSATSQPR 628

  Fly   517 T--PSKEESNDNIVLSKNTTSQADVCSQHDENDEAEIREPMD--------QVNSVVESDLGVRII 571
            |  |..:...:|.:|.|:..:... |.......|.....|::        |...|.|:..|.|..
  Rat   629 TSIPENKVKEENRLLFKSVENTVP-CELLACGTEISFPAPVEIEQARCLVQSMEVEETCAGARAA 692

  Fly   572 EDI---RLPKMANID---------HFAVK---VDNHGEAPAAVTDSALNQENLATQDQKICAEMK 621
            ..:   .||:.|:.|         |..:.   :...|:....::..|     .|..:..:...::
  Rat   693 ASVVMRVLPEHASEDFSQELGTKRHDDINSCDISEGGKKKVVLSPKA-----AAASESHLEPVVE 752

  Fly   622 DPTIFTTSDETPIKSATILYAKPDSTKLDHSDEHDEVILETAIDMLKKEQDAASTAESTYPKLRI 686
            :|:|      :|:..:              .|.:.:  ||.:::...|.::.:|..|...||
  Rat   753 EPSI------SPVNCS--------------GDNNPK--LEPSLEERPKVENKSSPLEPCLPK--- 792

  Fly   687 AEDAIEMALEQLHQQSPDET------VVTSTSNRAPQ-TPKSLITI----LTQTPKQADPLRSQT 740
                      ::...||.:|      :.|..||...| ...|:::|    |...|:...||.|..
  Rat   793 ----------EMFVPSPQKTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPV 847

  Fly   741 KSKTVSPMATPKKTATEKTPVKKRKVNMDSSPQVPAHDVT------IDETLGACSLQ-----DES 794
            :                  ||.| .::|:||..:|.:|.:      .:.||.....|     :..
  Rat   848 R------------------PVSK-VLSMESSCTIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENE 893

  Fly   795 STVTK--RCS-------LGHTDYQYEQIK--DEVILRVKRRGRRRKP-TPMEIP 836
            ..|.|  :||       |...:.:..:|:  ||..:..||..:..:| |..|:|
  Rat   894 KPVPKLDKCSEAESCKNLSVDELEEGEIRSDDEESVAQKRLEKSARPRTSTEVP 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLASH	NP_610845.1	None
Casp8ap2	NP_001101391.1	ADIP	<70..142	CDD:463295	20/71 (28%)
		CASP8AP2	1896..1960	CDD:213401