Protein Alignment FLASH and Casp8ap2

DIOPT Version :10

• Sequence 1: NP_610845.1
• Gene: FLASH / 36455
• FlyBaseID: FBgn0033806
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_006538012.1
• Gene: Casp8ap2 / 26885
• MGIID: 1349399
• Length: 2006
• Species: Mus musculus
• Alignment Length: 852
• Identity: 158/852 - (18%)
• Similarity: 292/852 - (34%)
• Gaps: 246/852 - (28%)

  Fly   117 KKIKTMEVNLQNLLDTAKAEVKRKETLIAELRNEKDDVCFRRKRARAFDVPGAREPESKRPKEFQ 181
            |.:.|::.:|..::::...:|| |..::..|                                |:
Mouse  1116 KSVSTLQKSLCEVIESNLKQVK-KNGIVDRL--------------------------------FE 1147

  Fly   182 STPIDVRKYPETNRNPFKTAAKDAAKDDARKMMTKKDDTTKVVSKDVE--RGVKSKE--DNKMAT 242
            ....|::|    ....|.....|...:..:|::.|..|:....:::.|  .|.|.||  .:....
Mouse  1148 QQQTDMKK----KLWKFVDEQLDYLFEKLKKILLKFCDSVNFENENSEGKLGKKYKERTQHSNCQ 1208

  Fly   243 NKDDDKKSSSKDDAWKSRTREDAKKSV--QRSKSPRPEHSKT----------------TDRKSTA 289
            .|..|.|...::...||....:.|.|:  ::|:....:.:||                :|....|
Mouse  1209 KKKMDNKEIRREKVLKSENTVNFKSSLGCEKSEEKHQDQNKTNASIVKHDVKRTFSTCSDNTKNA 1273

  Fly   290 QARRPDPHRS--RSPKHNSRRDHHRNQESSSRHAKRRSQSASPSKIQLPREKANAIITLTDDETN 352
            :.:.....:|  .:|:......|...:..:::||..:|            |::..|:|
Mouse  1274 ECKEQFLEKSCPSTPRPGKDEGHTEEEAQAAQHASAKS------------ERSFEILT------- 1319

  Fly   353 DQRSKSPVPVTVKLVTESQPAEKVVSNRRDAALETNANSSK---ESKVETKDITQPTNGLIAEPC 414
            :|::.|   :|..||:::|..|...|..:.:.|...:.:.|   |.|...|.:.:......|..|
Mouse  1320 EQQASS---LTFNLVSDAQMGEIFKSLLQGSDLLDTSGTEKAEWELKTPEKQLLESLKCESAPAC 1381

  Fly   415 IPKHEIIPGLSLINPESADFSKNEIKLDPVILQDRTEDSGHQLLNKEPIPKV---VVLEKCKNIL 476
            ..:..:..|.||.               |.::    .|....||:.|..|.:   :.|....::|
Mouse  1382 ATEELVSEGASLC---------------PKVI----SDDNWSLLSSEKGPSLSSGLSLPVHPDVL 1427

  Fly   477 AEDCPADEQPLDKFKDGKE----SEETQAKLDK--KEPFAVETAVETPSKEESNDNI----VLSK 531
            .|:|..:.......  ||:    ||:::..:..  .|..||...|.:|.|.:.:.:.    |||.
Mouse  1428 DENCMFEVSSNTAL--GKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFLKPEVLST 1490

  Fly   532 NTTSQA-------DVCSQHDENDEAEIREPMDQVNSVVESDLGVRIIEDI--------RLPKMAN 581
            :|..:.       |...:.::..|.:|...::..||..:|.........:        .||..|.
Mouse  1491 STPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAV 1555

  Fly   582 I-----DHFAVKVD----------NHGEAPAAVTDSALNQENLATQDQKICAEMKDPTIFTTSDE 631
            |     |||.||:.          .||    .|.:.:|.......::..:..| |:|.:|.::..
Mouse  1556 IMEKSNDHFIVKIRRATPSTSPGLKHG----VVAEESLTSLPRTGKEAGVATE-KEPNLFQSTVL 1615

  Fly   632 TPIKSATILYAKPDSTKLDHSDEHDEVILETAI-DMLKKEQDAAS-------TAESTYPKLRIAE 688
            .|:|.........|.:||.|.:::.  |::|.: |:.:..:||::       ..:..:...::.|
Mouse  1616 KPVKDLENTDKNIDKSKLTHEEQNS--IVQTQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWE 1678

  Fly   689 DAIEMALEQLHQQSPDETVVTSTSNRAPQT-----------PKSLITILTQTPKQADPLR-SQTK 741
            ..:...|::|...   |.:..|..|..|.|           .|||..::..|....|.|. |||
Mouse  1679 PKVSENLQELPSM---EKIPHSLDNHLPDTHIDLTKDSATETKSLGELMEVTVLNVDHLECSQT- 1739

  Fly   742 SKTVSPMATPKKTATEKTPVKKRKVNMD-------SSPQVPAHDVTIDETLGACS-LQDESS--- 795
                                     |:|       ||.|....|..||.|..|.| .::|.|
Mouse  1740 -------------------------NLDQDAEITCSSLQPDTIDAFIDLTHDASSESKNEGSEPV 1779

  Fly   796 ---------------TVTKRCSLGHTDYQYEQIKDEVIL----------RVKRRGRRRKPTP--- 832
                           ...|...:|..:...|.|.:|..:          .:||...:.:|..
Mouse  1780 LAVEGMGCQVICIDEDTNKEGKMGRANSPLESIVEETCIDLTSESPGSCEIKRHNLKSEPPSKLD 1844

  Fly   833 -MEIPTT 838
             :|:|.|
Mouse  1845 CLELPET 1851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLASH	NP_610845.1	None
Casp8ap2	XP_006538012.1	ADIP	<119..186	CDD:463295
		CASP8AP2	1940..2004	CDD:213401