Protein Alignment Orc3 and Orc3

DIOPT Version :10

• Sequence 1: NP_476904.1
• Gene: Orc3 / 36454
• FlyBaseID: FBgn0005654
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_056639.3
• Gene: Orc3 / 50793
• MGIID: 1354944
• Length: 715
• Species: Mus musculus
• Alignment Length: 782
• Identity: 259/782 - (33%)
• Similarity: 376/782 - (48%)
• Gaps: 143/782 - (18%)

  Fly     4 TISVSKGCFVYKNGATRAGKKAASKRK------------RPAAESSSLLGKEVVQQPFYEEYRKA 56
            |.||||||||:        |....|||            ...:|.|.|.         :|.|...
Mouse    10 TSSVSKGCFVF--------KPDFKKRKVFVPIEDYFNNEELDSEDSKLR---------FETYSLL 57

  Fly    57 WNQINDHIADLQHRSYARTLEQLVDFV------VGQAERDTPDEV----LPTAALLTGINQPDHL 111
            |.::......||........:.||||:      ..:..||...::    :|||||:.|:|..||.
Mouse    58 WQRMKSETEQLQEELNENLFDNLVDFLQKSHPEFQKNSRDWGSQMKFREIPTAALILGVNVTDHD 122

  Fly   112 SQFTALTQRLHAQRAAMVCVLQSRDCATLKAAVETLVFGLVEDNAEVEQMEDEDEDEDGAE-RDR 175
            ....:||:.|.......|..||::||..:|..::..          ..|:.|...|....| ...
Mouse   123 VILRSLTETLQNNVTPYVVSLQAKDCPDVKHFLQKF----------TSQLMDCCVDRHSKEVTSG 177

  Fly   176 KRLRRSQCTMKQLKSWY---TNNFDSE---QKRR--------QLVVILPDFECFNASVLQDLILI 226
            |.|:::..:|..|.|||   |...|.:   :||.        .:|:||...|.|.:.||||.|.|
Mouse   178 KALKKTNYSMDSLCSWYSAVTQKADHKVTIKKRTASGHWRSPPVVLILKSMESFTSKVLQDFITI 242

  Fly   227 LSAHCGSLPFVLVLGVATAMTAVHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAFH 291
            .|.|....|.:|:.|:||:...:|..||:.|||.:.:.:||:.:....|..||||:||:|::.|.
Mouse   243 SSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLLLTPQFPFK 307

  Fly   292 LSGKTFKFLTHIFLYYDFSIHGFIQGFKYCLMEHFFGGNAFALCTDYSKALGRIKQLTHEDMETI 356
            ||.|..:.||:||||:||||..||:|.|..|:|||:......||.|.|:|..|:...:....|.|
Mouse   308 LSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVLCCDLSEAKKRVNVFSVSQCENI 372

  Fly   357 RRLPSFRPYVEQINDCKRIIAVLTDDDYLKKKLPQLLRDCLLH------FLLFRCSLEFLTELVG 415
            |||||||.|||. ....:.:|:||::.:||:|...||.|  ||      ||:.||    |.....
Mouse   373 RRLPSFRRYVEN-QPLGKQVALLTNETFLKEKTQSLLED--LHVYHINYFLVLRC----LHNFTS 430

  Fly   416 DLPRCPLGKLRRELYVNCLNRAIISTPEYKECLQMLSFLSKDEFVAKVNRALERTEQFLVEEIAP 480
            .||:.|||:..||||..||.:.|..:.|||..||:|..|:|||.|:.:.|.:|     :::....
Mouse   431 SLPKYPLGRQIRELYCTCLEKKIWDSEEYKSALQLLRMLAKDELVSILQRCIE-----VLDSSTE 490

  Fly   481 LELGEACTAVLRPKLEAIRLAVDEVVKATMATITTTSPNETRQATDHLTPV----ASRQELKDQL 541
            .:||                                  |.|::..|.||..    |..:|.:|..
Mouse   491 KQLG----------------------------------NTTQKIKDFLTQFQNLDADSKEEEDAC 521

  Fly   542 --------------LQRSKEDKMRHQLNTPTTQFGRALQKTLQLIETQIVQDHLRALQDAPPIHE 592
                          ||:|..:....:.....|:|....:..:..|: .:|:|:|.. .::.|:||
Mouse   522 GSQPKGLQKTDLYHLQKSLLEMKELRRTKKPTKFEMLRENVMNFID-NLVRDYLLP-PESQPLHE 584

  Fly   593 LFVFSDIATVRRNIIGAPRAALHTALNNPHFYMQCKCCELQDQSLLVGTLPDLSVVYKLHLECGR 657
            :..||...|:|.::..|||.|||||||||::|::.:  ||  :..:..|.||:.:.|||||||..
Mouse   585 VVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNE--EL--EGCIPNTAPDICIAYKLHLECSL 645

  Fly   658 MINLFDWLQAFRSVVSDS---DHEEVAQEQIDPQIQARFTRAVAELQFLGYIKMSKRKTDHATRL 719
            :|||.||.:||.:||:.:   |......|::...|.|||.|||:||:.||:||.:|:||||..||
Mouse   646 LINLVDWAEAFATVVTAAEKMDANSTVSEEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARL 710

  Fly   720 TW 721
            ||
Mouse   711 TW 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orc3	NP_476904.1	ORC3_N	26..334	CDD:462070	106/344 (31%)
		ORC3_ins	345..597	CDD:466140	75/275 (27%)
		Orc3	<589..721	CDD:412052	63/134 (47%)
Orc3	NP_056639.3	ORC3_N	25..350	CDD:462070	112/361 (31%)
		ORC3_ins	361..592	CDD:466140	71/254 (28%)
		ORC_WH_C	603..712	CDD:436299	50/111 (45%)