DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc3 and orc3

DIOPT Version :9

Sequence 1:	NP_476904.1	Gene:	Orc3 / 36454	FlyBaseID:	FBgn0005654	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_997892.2	Gene:	orc3 / 334315	ZFINID:	ZDB-GENE-030131-6247	Length:	706	Species:	Danio rerio

Alignment Length:	782	Identity:	245/782 - (31%)
Similarity:	393/782 - (50%)	Gaps:	149/782 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TISVSKGCFVYKNGATRAGKKAASKRKRPAAESSSLLGKEVVQQPFYEEYR---KAWNQINDHIA 65
            |.||||||||:|:        |:.||||.......|:  |.......:.:|   |.|..:.....
Zfish     7 TSSVSKGCFVFKS--------ASKKRKRHVGLDEYLV--EADDDSGRDRFRICQKLWETVQTSTE 61

  Fly    66 DLQHRSYARTLEQLVDFV----VGQAE---RDTPDEVLPTAALLTGINQPDHLSQFTALTQRLHA 123
            ::|::...:.|:.||:|:    :|.:.   |....|: |||||:.|:|.|||...|.:|...|..
Zfish    62 EIQNQLNKKVLDSLVEFIKKHELGSSSDVWRQRTSEI-PTAALMLGVNVPDHAMTFRSLCNLLQD 125

  Fly   124 QRAAMVCVLQSRDCATLKAAVETLVFGLVEDNAEVEQMEDEDEDEDGAERDRKRLRRSQCTMKQL 188
            .....|..:.:::||.:|..::.::..|:.....|    ||:::||.|     ..:::|||:..|
Zfish   126 SVTPFVVSVHAKECAAVKHLIQKVLEQLMGKAVSV----DEEQEEDAA-----LPQKAQCTISAL 181

  Fly   189 KSWY-TNNFDSEQKR-----RQ---LVVILPDFECFNASVLQDLILILSAHCGSLPFVLVLGVAT 244
            ..|| |......||:     ||   :|||..|||.||:.||||.|.|.|.:...|||:.|.|:||
Zfish   182 CQWYKTATKKCSQKKNDNGLRQSLPVVVIFKDFEAFNSQVLQDFIHICSRYIQELPFIFVFGIAT 246

  Fly   245 AMTAVHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAFHLSGKTFKFLTHIFLYYDF 309
            :.:|:...||:.|||.:.:.|||:.:....|..|.||::|:..:.|.||.:..:.|..||||:||
Zfish   247 SPSAIQHRLPHSVSSLLCIEVFQSVSCTQHLASVFDKLILNAHFPFKLSSRVIQVLVGIFLYHDF 311

  Fly   310 SIHGFIQGFKYCLMEHFFGGNAFALCTDYSKALGRIKQLTHEDMETIRRLPSFRPYVEQINDCKR 374
            |:..|::|.::.::|||.......||....:||...|.|:.:::|.||.||||..||| ..:.:.
Zfish   312 SVQNFVKGLQFSMLEHFNSQPLSVLCCRKREALLCAKTLSQQNVERIRHLPSFMRYVE-TQEPEE 375

  Fly   375 IIAVLTDDDYLKKKLPQLLRDCLLH------FLLFRCSLEFLTELVGDLPRCPLGKLRRELYVNC 433
            .:.:||.|.::|:....||:.  ||      |.:.:|    |..|...||:.||||..|||:|:|
Zfish   376 QVKLLTSDQHVKEVCQTLLKS--LHKYHKNYFPILQC----LHSLTSSLPKFPLGKHIRELHVSC 434

  Fly   434 LNRAIISTPEYKECLQMLSFLSKDEFVAKVNRALERTEQFLVEEIAPLELGEACTAVLR----PK 494
            ..:.:..|.||...:|:|..|:|:|.||.:                     :.|:.:|:    .:
Zfish   435 NEKNLWETEEYDSAMQLLRILAKNELVAAL---------------------QGCSDILQSASTKR 478

  Fly   495 LEAIRLAVDEVVKATMATITTTSPNETRQATDHLTPVASRQELKDQLLQRSKEDKMRHQLNTPTT 559
            ::.:...|::.:. .:.|:.:.|.                   :|..:..:...|:.:|..|...
Zfish   479 MQTVFQQVEDFIN-RLETLESVSS-------------------EDSSVNGAISGKIDYQRKTDLF 523

  Fly   560 QFGRALQKTL--------------QLIETQIVQ------------DHLRALQDAPPIHELFVFSD 598
            |    |||||              :::.:|:::            .||:      |:.|:..||.
Zfish   524 Q----LQKTLLEKESRRTKKMSPFEVLRSQVIEFIDSLVREYLTPAHLQ------PLSEVCYFSS 578

  Fly   599 IATVRRNIIGAPRAALHTALNNPHFYMQCKCCELQDQSLL--VGTL----PDLSVVYKLHLECGR 657
            ...:|:.:...||.::..||::|::|       ||::||.  .||:    |||.:||||||||||
Zfish   579 SGILRQRLNVTPRTSIQAALSHPYYY-------LQNESLKTNAGTISSAAPDLCIVYKLHLECGR 636

  Fly   658 MINLFDWLQAFRSVVS---DSDHEEVAQEQIDPQIQARFTRAVAELQFLGYIKMSKRKTDHATRL 719
            :|||:|||:||.:|:|   |.|.:.....|:|....|||.:||:|::|||::|.:|:||||..||
Zfish   637 LINLYDWLEAFVTVLSAAEDQDADSGDHGQLDSLKHARFIQAVSEMEFLGFVKSTKQKTDHVARL 701

  Fly   720 TW 721
            ||
Zfish   702 TW 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc3	NP_476904.1	ORC3_N	26..334	CDD:284456	104/326 (32%)
orc3	NP_997892.2	ORC3_N	22..336	CDD:284456	104/325 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596855
Domainoid	1	1.000	161	1.000	Domainoid score	I4007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8225
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2320
OMA	1	1.010	-	-		QHG52680
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006551
OrthoInspector	1	1.000	-	-		oto41694
orthoMCL	1	0.900	-	-		OOG6_104370
Panther	1	1.100	-	-	LDO	PTHR12748
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R872
SonicParanoid	1	1.000	-	-		X5544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930