DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc3 and ORC3

DIOPT Version :9

Sequence 1:	NP_476904.1	Gene:	Orc3 / 36454	FlyBaseID:	FBgn0005654	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_862820.1	Gene:	ORC3 / 23595	HGNCID:	8489	Length:	712	Species:	Homo sapiens

Alignment Length:	780	Identity:	251/780 - (32%)
Similarity:	389/780 - (49%)	Gaps:	135/780 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TISVSKGCFVYKNGATRAGKKAASKRK------------RPAAESSSLLGKEVVQQPFYEEYRKA 56
            |.|:||||||:|..        :.|||            :...|.|.|.         :|.|:..
Human     3 TSSMSKGCFVFKPN--------SKKRKISLPIEDYFNKGKNEPEDSKLR---------FETYQLI 50

  Fly    57 WNQINDHIADLQHRSYARTLEQLVDFV------VGQAERDTPDEV----LPTAALLTGINQPDHL 111
            |.|:......||........:.|::|:      ..:..||...::    :|||||:.|:|..||.
Human    51 WQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHD 115

  Fly   112 SQFTALTQRLHAQRAAMVCVLQSRDCATLKAAVETLVFGLVEDNAEVEQMEDEDEDEDGAERDRK 176
            ..|.:||:.|.......|..||::||..:|..::.|:..|::...:::..|:|..        ..
Human   116 LTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESV--------HV 172

  Fly   177 RLRRSQCTMKQLKSWY---TNNFDSE--QKRR---------QLVVILPDFECFNASVLQDLILIL 227
            ..|::..:|..|.|||   |...|.:  .|:|         .:||||.|.|.|...||||.|:|.
Human   173 TQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIIS 237

  Fly   228 SAHCGSLPFVLVLGVATAMTAVHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAFHL 292
            |.|....|.:|:.|:||:...:|..||:.|||.:.:.:||:.:....|..||||:||:.::.|.:
Human   238 SQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKI 302

  Fly   293 SGKTFKFLTHIFLYYDFSIHGFIQGFKYCLMEHFFGGNAFALCTDYSKALGRIKQLTHEDMETIR 357
            :.|..:.||:||||:|||:..||:|.:..|:|||:......||.:..:|..||..|::...|.||
Human   303 NEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSNNQCENIR 367

  Fly   358 RLPSFRPYVEQINDCKRIIAVLTDDDYLKKKLPQLLRDCLLH------FLLFRCSLEFLTELVGD 416
            ||||||.|||: ...::.:|:||::.|||::...||.:  ||      ||:.||    |.:....
Human   368 RLPSFRRYVEK-QASEKQVALLTNERYLKEETQLLLEN--LHVYHMNYFLVLRC----LHKFTSS 425

  Fly   417 LPRCPLGKLRRELYVNCLNRAIISTPEYKECLQMLSFLSKDEFVAKVNRAL-------------- 467
            ||:.|||:..||||..||.:.|..:.||...||:|..|:|||.:..:.:..
Human   426 LPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGST 490

  Fly   468 -ERTEQFLVEEIAPLELGEACTAVLRPKLEAIRLAVDEVVKATMATITTTSPNETRQATD--HLT 529
             :|.|:||.:                  .:::.....|...|      :.|..:..|.||  ||.
Human   491 AKRIEEFLAQ------------------FQSLDAETKEEEDA------SGSQPKGLQKTDLYHLQ 531

  Fly   530 PVASRQELKDQLLQRSKEDKMRHQLNTPTTQFGRALQKTLQLIETQIVQDHLRALQDAPPIHELF 594
              .|..|:|:  |:|||:.          |:|....:..:..|:. :|:::|.. .:..|:||:.
Human   532 --KSLLEMKE--LRRSKKQ----------TKFEVLRENVVNFIDC-LVREYLLP-PETQPLHEVV 580

  Fly   595 VFSDIATVRRNIIGAPRAALHTALNNPHFYMQCKCCELQDQSLLVGTLPDLSVVYKLHLECGRMI 659
            .||....:|.::..|||.|||||||||::|::.:..: .::..:....||:.:.|||||||.|:|
Human   581 YFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALK-SEEGCIPNIAPDICIAYKLHLECSRLI 644

  Fly   660 NLFDWLQAFRSVVSDS---DHEEVAQEQIDPQIQARFTRAVAELQFLGYIKMSKRKTDHATRLTW 721
            ||.||.:||.:||:.:   |......|:::..|.|||.|||:||:.||:||.:|:||||..||||
Human   645 NLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 709

Fly 722 721
Human 710 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc3	NP_476904.1	ORC3_N	26..334	CDD:284456	102/343 (30%)
ORC3	NP_862820.1	ORC3_N	18..344	CDD:399784	102/342 (30%)
ORC3	NP_862820.1	ORC_WH_C	597..709	CDD:407969	52/112 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160477
Domainoid	1	1.000	155	1.000	Domainoid score	I4249
eggNOG	1	0.900	-	-		E1_KOG2538
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8225
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2245
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52680
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006551
OrthoInspector	1	1.000	-	-		oto88744
orthoMCL	1	0.900	-	-		OOG6_104370
Panther	1	1.100	-	-	LDO	PTHR12748
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R872
SonicParanoid	1	1.000	-	-		X5544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790