DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc3 and orc3

DIOPT Version :9

Sequence 1:	NP_476904.1	Gene:	Orc3 / 36454	FlyBaseID:	FBgn0005654	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_031757319.1	Gene:	orc3 / 100125181	XenbaseID:	XB-GENE-984200	Length:	716	Species:	Xenopus tropicalis

Alignment Length:	778	Identity:	257/778 - (33%)
Similarity:	389/778 - (50%)	Gaps:	134/778 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TISVSKGCFVYKNGATRAGKKAASKRKRPAAE-----SSSLLGKEVVQQPFYEEYRKAWNQINDH 63
            |.||||||||:         |.::|:|:.:..     :..|...|..::.| |..:..|.|:...
Frog    10 TSSVSKGCFVF---------KPSTKKKKTSLTVADYFNEGLKDSEDGKKRF-ESCQLLWQQMKSQ 64

  Fly    64 IADLQHRSYARTLEQLVDFVVGQAERDTPDE-----------VLPTAALLTGINQPDHLSQFTAL 117
            ...||.....|..|.|:.| :.::..|..|:           .:|||||:.|:|..||...|.:|
Frog    65 TEQLQEELNKRLFENLIGF-LRKSHADFHDKKDDWSCRMRASEIPTAALVLGVNVTDHDLTFNSL 128

  Fly   118 TQRLHAQRAAMVCVLQSRDCATLKAAVETLVFGLVEDNAEVEQMEDEDEDEDGAERDRKRLRRSQ 182
            ...||......|.:|||::|..:|..::.|:..|:.:.|::|.  ||:|::....:     |:..
Frog   129 ADILHETITPYVVLLQSKECPGIKQLLQKLLIQLMGNTADIEL--DEEEEQVTISQ-----RKMN 186

  Fly   183 CTMKQLKSWY---TNNFDSEQKRRQ----------LVVILPDFECFNASVLQDLILILSAHCGSL 234
            |::..|..||   |....|.:|:|.          :|||..|.|.|.|||||:.|:|.|.:...|
Frog   187 CSLASLSGWYKRATKKPASPKKKRSSTSTHWESPPVVVIFKDLESFTASVLQEFIVISSGYVQEL 251

  Fly   235 PFVLVLGVATAMTAVHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAFHLSGKTFKF 299
            |.|||.|:||:...:|..|.:.|||::.:.:||:.:....|..|:|::||:..:.|.|||:..:.
Frog   252 PLVLVFGIATSPMIIHRLLSHSVSSRLCIELFQSMSCTEHLATVVDQLLLTNHFPFKLSGRALQV 316

  Fly   300 LTHIFLYYDFSIHGFIQGFKYCLMEHFFGGNAFALCTDYSKALGRIKQLTHEDMETIRRLPSFRP 364
            |..||||:|||:..||:|.:..::|||:......||....::..|||.|:|...|.||.|.||..
Frog   317 LITIFLYHDFSVQNFIKGLQLSVVEHFYTQPLSVLCCSLPESRKRIKNLSHAQCENIRHLSSFMS 381

  Fly   365 YVEQINDCKRIIAVLTDDDYLKKKLPQLLR-------------DCLLHFLLFRCSLEFLTELVGD 416
            |||. ...:..:.:||:|.:||:...:.|.             .||.||...
Frog   382 YVES-QTPENQVKLLTNDSFLKEMTQEFLERLTSYHENFTPILRCLHHFTCI------------- 432

  Fly   417 LPRCPLGKLRRELYVNCLNRAIISTPEYKECLQMLSFLSKDEFVAKVNRALERTEQFLVEEIAPL 481
            ||:.||||..||||..||.:.:..|.:|...|.:|..|:|||.|..:.:
Frog   433 LPKYPLGKQVRELYCACLEKKVWETEDYNSALLLLRMLAKDEIVTTLQK---------------- 481

  Fly   482 ELGEACTAVLRP-----------KLEAIRLAVDEVVKATM-ATITTTSPNETRQATDHLTPVASR 534
                 |.|||.|           |||...:....:.:.|: .....|||.:..|....|
Frog   482 -----CVAVLTPYSEKELGHTLEKLEEFLIHFQSLEENTLNGEDEDTSPQKALQKKTDL------ 535

  Fly   535 QELKDQLLQRSKEDKMRHQLNTPTTQFGRALQKTLQLIETQIVQDHLRALQDAPPIHELFVFSDI 599
            .:|:.:||: .||.:...:|    |:|....|..:..|:. ||:::| ...:..|:||:..||..
Frog   536 YQLQKKLLE-MKETRRAKKL----TKFEMLRQDVVDFIDC-IVREYL-VPPEMLPLHEVVYFSAA 593

  Fly   600 ATVRRNIIGAPRAALHTALNNPHFYMQCKCCELQDQSLLVGTL-PDLSVVYKLHLECGRMINLFD 663
            :|:||::..|||.|||||||||..|::    .|::::..|..: ||:.:.|||||||||:|||:|
Frog   594 STLRRHLNAAPRVALHTALNNPASYLK----TLENEAGSVSNVAPDICIAYKLHLECGRLINLYD 654

  Fly   664 WLQAFRSVV-----SDSDHEEVAQEQIDPQIQARFTRAVAELQFLGYIKMSKRKTDHATRLTW 721
            ||:||.:||     ||||    :.:|:|....|||.|||:||:.||::|.:|:||||..||||
Frog   655 WLEAFSTVVHAGEGSDSD----SAQQVDEVTHARFIRAVSELELLGFVKPTKQKTDHVARLTW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc3	NP_476904.1	ORC3_N	26..334	CDD:284456	103/336 (31%)
orc3	XP_031757319.1	ORC3_N	31..351	CDD:399784	101/328 (31%)
orc3	XP_031757319.1	ORC_WH_C	605..713	CDD:407969	58/115 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4082
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8225
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2164
OMA	1	1.010	-	-		QHG52680
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006551
OrthoInspector	1	1.000	-	-		oto102614
Panther	1	1.100	-	-	LDO	PTHR12748
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R872
SonicParanoid	1	1.000	-	-		X5544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100