DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INSRR and Sdr

DIOPT Version :9

Sequence 1:	NP_055030.1	Gene:	INSRR / 3645	HGNCID:	6093	Length:	1297	Species:	Homo sapiens
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	905	Identity:	261/905 - (28%)
Similarity:	410/905 - (45%)	Gaps:	165/905 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     8 PWGACLPVIFLSLG------FGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGE 66
            |....:|:|.|.||      ...|....|.||:| :::|:||:|:||:.|.||:::..:
  Fly    14 PISIAVPLILLFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71

Human    67 DFRGLS--------FPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTR-LFLGYALVIFEMPH 122
            |...:|        ...:|:::|||:::|..||.||:.:||.|.:|||.. ||..|:||::|..:
  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136

Human   123 LRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANH--IVGNKLGEECADVCPGVLG 185
            ||::.|..|..:..|.:|||.|..||.:.|:||..|.......|  :..|:...:| .:| |.|.
  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-PLC-GSLS 199

Human   186 AAGEPCAKTTFSGHTDYRCWTSSHCQ--------RVCPCPHGM-ACTARGECCHTECLGGCSQPE 241
            |..|      |..::..|||..:..|        :.||...|: .|.:.|:||...|:.||..
  Fly   200 ADFE------FIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYS-- 256

Human   242 DPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQG-SCLAQCP 305
              :.|..|.:...:..|:..| ..:|:....||:....|..|..:|       :.:| .|:.:||
  Fly   257 --QNCSLCANYQGRMGCVNQC-VASYELNKRRCIGHRECRELGRIP-------LIRGYQCVKKCP 311

Human   306 SGFTRNSSSIFCHKCEGLCPKECK--VGTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQ- 367
            .    |...|...|....|..||.  ...|:...::..||   |..:.|||.:.|.   |::.:
  Fly   312 G----NQKEILVAKGIIHCQVECNGDFHVKSAADLEVLQD---CVTINGSLTIELT---NIKEKI 366

Human   368 ---LQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWV 429
               |:::|..|:.|||:||:.||..|:||.|.:||..||||.:|:..|.|||::|.:|:.:  |.
  Fly   367 VDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHI--WP 429

Human   430 AAGLT-IPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNV 493
            ...|. |..|.::|..|||||.|.|::|:....:....:.|:::|.:||:|..|..........|
  Fly   430 PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLNPKV 494

Human   494 TE----ADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSR 554
            .:    |.||:|.:..:|.:|.  |:.:..:|||:|.||.|.:.|...||..:| |:||....||
  Fly   495 EDLNSTAVRIILDYMDWEGMET--LIGYSYHYKEAPVQNVTMYDGRHGCGHDNW-LMDVVPNQSR 556

Human   555 TQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSS 619
            ..    .::.|||:||||.||:  |||..|......|.|.|.|.:|||..|:....:..:|..||
  Fly   557 RH----VISGLKPYTQYAYFVK--TLTRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEISS 615

Human   620 HLLVRWKPPTQRNGNLTYYLVLWQRL-----AEDGDLYLN---------DYCHRGLRLPTSNNDP 670
            .:|:.|.||.:.||.:..|.|..::.     |:|.: |:|         | |.....||..:. |
  Fly   616 QILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKN-YVNVELENAKDID-CECAGVLPYYSG-P 677

Human   671 RFDGEDGDPEAEMESDCCPCQHPPPGQVLPPL-------EAQEASFQK--KFENFL--------- 717
            :.|.||...:.::..:          ..||.|       :.:...|:|  .:|:.|
  Fly   678 QPDDEDYYNKEQITYE----------DALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPT 732

Human   718 HNAITIP------ISPWKVTSIN--------KSPQR---DSGRHR---RAAGPLRLGGNSSDFEI 762
            ....|.|      ::..::.:||        :..||   |..:|:   |.|.|.....::|..:.
  Fly   733 RPPTTTPAPTNATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQ 797

Human   763 QEDKVPRERAV----LSGLRHF---------TEYRIDIHACNHAAHTVGCSAATFVFART 809
            .|:|...|..:    |.|.:||         |.|||.|.||.... ..|||.......:|
  Fly   798 VEEKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRACVEGV-VNGCSTPAEAVIKT 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INSRR	NP_055030.1	Recep_L_domain	47..158	CDD:279382	42/119 (35%)
		Furin-like	173..326	CDD:279142	39/162 (24%)
		FU	228..275	CDD:238021	11/46 (24%)
		Recep_L_domain	346..460	CDD:279382	46/118 (39%)
		FN3	490..600	CDD:238020	41/113 (36%)
		FN3	605..>649	CDD:238020	13/48 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..687		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..758		9/39 (23%)
		FN3	819..908	CDD:238020
		PTKc_InsR_like	972..1248	CDD:173625
		Pkinase_Tyr	979..1246	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1297
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	42/120 (35%)
		Furin-like	209..332	CDD:279142	34/138 (25%)
		Recep_L_domain	347..461	CDD:279382	47/121 (39%)
		FN3	491..578	CDD:214495	35/95 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8236
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820