Protein Alignment Spt-I and SPTLC2

DIOPT Version :9

• Sequence 1: NP_610842.1
• Gene: Spt-I / 36448
• FlyBaseID: FBgn0086532
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_004854.1
• Gene: SPTLC2 / 9517
• HGNCID: 11278
• Length: 562
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 141/506 - (27%)
• Similarity: 233/506 - (46%)
• Gaps: 82/506 - (16%)

  Fly     7 FNEIGSIFRNTPTFALVLETLLLITVIWLLLHRRGGGRRRQLTK-------EEEDRIIADYEPEP 64
            |||   .|..||....|| |.:...|:.|..:.|...|..::.|       ||:...::.|:
Human    59 FNE---AFEETPMLVAVL-TYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQ--- 116

  Fly    65 LVADTDPNHPLLHTRVVQSRV------------GKRIQV---DGHD--------------CLNLG 100
                   :....:||.:..|:            |.|:.:   ..||              .:|:|
Human   117 -------DFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMG 174

  Fly   101 SHNYLGFLEDQEILEE-ACKSLRKYGVGSCGPRGFYGTMDVHLDLEDRIAKFMGLEEAIVYSYGF 164
            |:|||||..:....:| |.|.|.:||.|.|..|...|.:|.|.:||:.:|:|:|:|.|:.|..||
Human   175 SYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGF 239

  Fly   165 STVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVEDLERLLIEQEKRDQKNPK 229
            :|.:..|||...:|.||..||..:.::..|...|.:||..||||:::.||:||.:.....|...:
Human   240 ATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTR 304

  Fly   230 KAAKTRRFLVAEGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFGTLGQGGHGVTEHFNVDRD 294
            :..| :..::.||||...|.|..||:::||::|||..|::||:.|.|.||..|.||.|:|.:|.:
Human   305 RPWK-KILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPE 368

  Fly   295 EVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSASLPPMLTQAAISAL------DRFE 353
            :||::......|....||:..|...:.::.|......:::.||.|.:.:..|:::      |...
Human   369 DVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTS 433

  Fly   354 REPQIFEQLQAKSKTLHQKFLRFSKLTLRGDEVSPVKHLYLAQPAE--NFDKELKLLTELADKCI 416
            ...:..:|| |::....::.|:.....:.|:|.|||..|.|..||:  .|.:|:          :
Human   434 LGKECVQQL-AENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREM----------L 487

  Fly   417 ARGVAVVQAAYLQNRERQPVRPSIRIAVNRLLESSE----IDNAFEVIESV 463
            .|.:.||...:       |..|.|.......|.::.    :|.|.:.|:.|
Human   488 KRNIGVVVVGF-------PATPIIESRARFCLSAAHTKEILDTALKEIDEV 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	135/491 (27%)
		BioF	79..463	CDD:223234	122/425 (29%)
SPTLC2	NP_004854.1	AAT_I	67..542	CDD:418510	136/495 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820