DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spt-I and alas2

DIOPT Version :9

Sequence 1:	NP_610842.1	Gene:	Spt-I / 36448	FlyBaseID:	FBgn0086532	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_571757.1	Gene:	alas2 / 64607	ZFINID:	ZDB-GENE-001229-1	Length:	583	Species:	Danio rerio

Alignment Length:	279	Identity:	81/279 - (29%)
Similarity:	135/279 - (48%)	Gaps:	22/279 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PLLHTRVVQSRVGKRIQVDGHDCLNLGSHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTM 138
            |......:..|:|.::.|   .|    |::|||......:::....:|:|:|.|:.|.|...||.
Zfish   171 PFAEDYSIAGRLGSQVSV---WC----SNDYLGMSRHPRVVKAIGDALKKHGAGAGGTRNISGTS 228

  Fly   139 DVHLDLEDRIAKFMGLEEAIVYSYGFSTVASAIPAYAKR--GDLIFVDEAVNFAIQKGLDASRST 201
            :.|:.||:.:|:....:.|:|:|..|....|.:...||.  |..|:.|...:.::.:|:..|.:.
Zfish   229 NYHVALENELARLHQKDGALVFSSCFVANDSTLFTLAKMLPGCEIYSDMGNHASMIQGIRNSGAK 293

  Fly   202 IVFFKHNDVEDLERLLIEQEKRDQKNPKKAAKTRRFLVA-EGIYMNTGEICPLPDLVALRQKYKL 265
            ...|:|||...||.||   .:.|...||        :|| |.::...|.||||.:|..:..||..
Zfish   294 RFIFRHNDASHLEELL---SRSDPLTPK--------IVAFETVHSMDGAICPLEELCDVAHKYGA 347

  Fly   266 RLFIDESISFGTLGQGGHGVTEHFNVDRDEVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLG 330
            ..|:||..:.|..|..|.||.|..|| ..::|::|..:..:...|||:...:..:.:..|....|
Zfish   348 LTFVDEVHAVGLYGAHGAGVGERDNV-MHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAG 411

  Fly   331 YIFSASLPPMLTQAAISAL 349
            :||:.|||||:...|:.::
Zfish   412 FIFTTSLPPMVLAGALESV 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	81/279 (29%)
Spt-I	NP_610842.1	BioF	79..463	CDD:223234	80/274 (29%)
alas2	NP_571757.1	Preseq_ALAS	3..98	CDD:286162
		AAT_I	138..542	CDD:302748	81/279 (29%)
		BioF	138..535	CDD:223234	81/279 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810