DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt-I and Sptlc2

DIOPT Version :9

Sequence 1:	NP_610842.1	Gene:	Spt-I / 36448	FlyBaseID:	FBgn0086532	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001032174.1	Gene:	Sptlc2 / 366697	RGDID:	1305447	Length:	560	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	137/506 - (27%)
Similarity:	232/506 - (45%)	Gaps:	82/506 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FNEIGSIFRNTPTFALVLETLLLITVIWLLLHRRGGGRRRQLTK-------EEEDRIIADYEPEP 64
            |||   .|..||....|| |.:...|:.|..:.|...|..::.|       ||:...::.|:
  Rat    57 FNE---AFEETPMLVAVL-TYVGYGVLTLFGYLRDFLRHWRIEKCHHATEREEQKDFVSLYQ--- 114

  Fly    65 LVADTDPNHPLLHTRVVQSRV------------GKRIQV---DGHD--------------CLNLG 100
                   :....:||.:..|:            |.::.:   ..||              .:|:|
  Rat   115 -------DFENFYTRNLYMRIRDNWNRPICSVPGAKVDIMERQSHDYNWSFKYTGNIIKGVINMG 172

  Fly   101 SHNYLGFLEDQEILEE-ACKSLRKYGVGSCGPRGFYGTMDVHLDLEDRIAKFMGLEEAIVYSYGF 164
            |:|||||..:....:| |.:.|:.||.|.|..|...|.:|.|.:||..:|:|:|:|.|:.|..||
  Rat   173 SYNYLGFARNTGSCQEAAAEVLKTYGAGVCSTRQEIGNLDKHEELEKLVARFLGVEAALTYGMGF 237

  Fly   165 STVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVEDLERLLIEQEKRDQKNPK 229
            :|.:..|||...:|.||..||..:.::..|...|.:||..||||:::.||:||.:.....|...:
  Rat   238 ATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTR 302

  Fly   230 KAAKTRRFLVAEGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFGTLGQGGHGVTEHFNVDRD 294
            :..| :..::.||||...|.|..||:::||::|||..|::||:.|.|.||..|.||.::|.:|.:
  Rat   303 RPWK-KILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPSGRGVVDYFGLDPE 366

  Fly   295 EVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSASLPPMLTQAAISAL------DRFE 353
            :||::......|....||:..|...:.::.|......:::.|:.|.:.:..|:::      |...
  Rat   367 DVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSMSPPVMEQIITSMKCIMGQDGTS 431

  Fly   354 REPQIFEQLQAKSKTLHQKFLRFSKLTLRGDEVSPVKHLYLAQPAE--NFDKELKLLTELADKCI 416
            ...:..:|| |::....::.|:.....:.|:|.|||..|.|..||:  .|.:|:          :
  Rat   432 LGKECIQQL-AENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREM----------L 485

  Fly   417 ARGVAVVQAAYLQNRERQPVRPSIRIAVNRLLESSE----IDNAFEVIESV 463
            .|.:.||...:       |..|.|.......|.::.    :|.|.:.|:.|
  Rat   486 KRNIGVVVVGF-------PATPIIESRARFCLSAAHTKEILDTALKEIDEV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	131/491 (27%)
Spt-I	NP_610842.1	BioF	79..463	CDD:223234	118/425 (28%)
Sptlc2	NP_001032174.1	AAT_I	65..542	CDD:418510	132/495 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820