DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spt-I and Sptlc1

DIOPT Version :9

Sequence 1:	NP_610842.1	Gene:	Spt-I / 36448	FlyBaseID:	FBgn0086532	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001101876.1	Gene:	Sptlc1 / 361213	RGDID:	1307140	Length:	473	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	234/452 - (51%)
Similarity:	312/452 - (69%)	Gaps:	1/452 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PTFALVLETLLLITVIWLLLHRRGG-GRRRQLTKEEEDRIIADYEPEPLVADTDPNHPLLHTRVV 81
            |.:.|:||.:|::.:|.|:..:... ..|..||.:|::.:|.:::|||||.....|||.|:..:|
  Rat    21 PAYHLILEGILILWIIRLVFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSRNHPALNYNIV 85

  Fly    82 QSRVGKRIQVDGHDCLNLGSHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTMDVHLDLED 146
            .......|.|:|.:|:|..|.|:||.|.:..:...|..||:|||||:|||||||||.|||||||:
  Rat    86 SGPPTHNIVVNGKECVNFASFNFLGLLANPRVKAAAFASLKKYGVGTCGPRGFYGTFDVHLDLEE 150

  Fly   147 RIAKFMGLEEAIVYSYGFSTVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVE 211
            |:||||..||||:|||||||:|||||||:||||::|||.|..|||||||.||||.|..||||||.
  Rat   151 RLAKFMKTEEAIIYSYGFSTIASAIPAYSKRGDIVFVDSAACFAIQKGLQASRSDIKLFKHNDVA 215

  Fly   212 DLERLLIEQEKRDQKNPKKAAKTRRFLVAEGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFG 276
            ||||||.|||..|||||:||..||||:||||:|||||.|||||:||.|:.|||.|:|::||:|||
  Rat   216 DLERLLKEQEIEDQKNPRKARVTRRFIVAEGLYMNTGTICPLPELVRLKYKYKARIFLEESLSFG 280

  Fly   277 TLGQGGHGVTEHFNVDRDEVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSASLPPML 341
            .||:.|.|||||:.:..|::|||||.||.::|:|||||.|..|:.:||||||.||.|||||||:|
  Rat   281 VLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLL 345

  Fly   342 TQAAISALDRFEREPQIFEQLQAKSKTLHQKFLRFSKLTLRGDEVSPVKHLYLAQPAENFDKELK 406
            ..|||.||:..|..|.||..|:.|.:|:|:.....|.|.:.|:.:.|..||.|.:...:.::::|
  Rat   346 AAAAIEALNIMEENPGIFAVLKKKCQTIHKSLQGVSGLKVVGESLCPALHLQLEESTGSRERDMK 410

  Fly   407 LLTELADKCIARGVAVVQAAYLQNRERQPVRPSIRIAVNRLLESSEIDNAFEVIESVSSSVL 468
            ||.|:.::|:.:|:|:.||.||...|:....||||:.|.......|:..|...|...:.:||
  Rat   411 LLQEIVEQCMNKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTDEELQRAAATIREAAQAVL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	231/446 (52%)
Spt-I	NP_610842.1	BioF	79..463	CDD:223234	211/383 (55%)
Sptlc1	NP_001101876.1	Beta_elim_lyase	11..472	CDD:354370	232/450 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341030
Domainoid	1	1.000	424	1.000	Domainoid score	I600
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4681
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1460
OMA	1	1.010	-	-		QHG54231
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	1	1.000	-	-		FOG0004733
OrthoInspector	1	1.000	-	-		oto95847
orthoMCL	1	0.900	-	-		OOG6_102559
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3331
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770