DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spt-I and SPBC18E5.02c

DIOPT Version :9

Sequence 1:	NP_610842.1	Gene:	Spt-I / 36448	FlyBaseID:	FBgn0086532	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_595848.1	Gene:	SPBC18E5.02c / 2540820	PomBaseID:	SPBC18E5.02c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	476	Identity:	191/476 - (40%)
Similarity:	280/476 - (58%)	Gaps:	33/476 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IGSIFRNTP--TFALVLETLLLITVIWLLLHR---RGGGRRRQLTKEEEDRIIADYEPEPLVAD- 68
            |.|.::|.|  ||   :|.|||:...:.:|.:   .......:.|::|.:.::.|::||||||:
pombe    39 IKSSYQNDPLRTF---IEFLLLVFAAYYVLRKPRTSPDNNYVEFTEKEINELVDDWKPEPLVAEL 100

  Fly    69 TD------PNHPL-----LHTRVVQSRVGKRIQVDGHDCLNLGSHNYLGFLEDQEILEEACKSLR 122
            ||      .:.|:     |||::          :||....|..|.|:|...|::.|.|.|..:||
pombe   101 TDVEKLELKSIPVLESVHLHTKL----------IDGRPITNFASFNFLDLAENKHITECAVATLR 155

  Fly   123 KYGVGSCGPRGFYGTMDVHLDLEDRIAKFMGLEEAIVYSYGFSTVASAIPAYAKRGDLIFVDEAV 187
            :.|:|:|||.|||||.|.||.||..||.|:|:|.||||:..|.|::|.|||::||||::.||||.
pombe   156 ECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERAIVYAQSFQTISSVIPAFSKRGDILVVDEAC 220

  Fly   188 NFAIQKGLDASRSTIVFFKHNDVEDLERLLIEQEKRDQKNPKKAAKTRRFLVAEGIYMNTGEICP 252
            |||||||:..||:||.:||||:::||||:|  ||..|.........||||::.|||..|.|::..
pombe   221 NFAIQKGIQISRTTIRYFKHNNMKDLERIL--QELEDDFVKHNRPLTRRFIITEGISENYGDMVD 283

  Fly   253 LPDLVALRQKYKLRLFIDESISFGTLGQGGHGVTEHFNVDRDEVDLISAGMEGSMATVGGFCVGS 317
            |..:|||::|||.||.:||:.||||.|:.|.|:||||.|...:|::|...:..|:|..||||.||
pombe   284 LTKIVALKKKYKYRLILDETWSFGTCGRTGKGLTEHFGVPPTDVEIIIGSLTTSLAGGGGFCAGS 348

  Fly   318 HFIAEHQRLSGLGYIFSASLPPMLTQAAISALDRFERE-PQIFEQLQAKSKTLHQKFLRFSKLTL 381
            ..:.|||||||:.||:||:||..|..||..|:....|: ..:...|::||...|.|..|......
pombe   349 ELMVEHQRLSGMAYIYSAALPASLAVAAYEAISILSRDGGSMLNDLRSKSALFHAKLSRNKFFET 413

  Fly   382 RGDEVSPVKHLYLAQPAENFDKELKLLTELADKCIARGVAVVQAAYLQNRERQPVRPSIRIAVNR 446
            ..|..||:.||.......:.||::.||.|:.:.|||.|..:.:|..:::.||..|:||:||.::.
pombe   414 SSDIESPIIHLRFKDKDISHDKQVFLLEEIVELCIAEGFLIARAKRVESLERVKVQPSLRICIST 478

  Fly   447 LLESSEIDNAFEVIESVSSSV 467
            ...:.||:....:|:..:..|
pombe   479 GHSAEEIEKLALLIKEKTEIV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	185/462 (40%)
Spt-I	NP_610842.1	BioF	79..463	CDD:223234	164/384 (43%)
SPBC18E5.02c	NP_595848.1	AAT_I	51..493	CDD:302748	184/456 (40%)
SPBC18E5.02c	NP_595848.1	BioF	108..494	CDD:223234	168/397 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	303	1.000	Domainoid score	I254
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4681
Inparanoid	1	1.050	323	1.000	Inparanoid score	I541
OMA	1	1.010	-	-		QHG54231
OrthoFinder	1	1.000	-	-		FOG0004733
OrthoInspector	1	1.000	-	-		oto100633
orthoMCL	1	0.900	-	-		OOG6_102559
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R651
SonicParanoid	1	1.000	-	-		X3331
TreeFam	1	0.960	-	-
	14	13.860