Protein Alignment Spt-I and ALAS2

DIOPT Version :10

• Sequence 1: NP_610842.1
• Gene: Spt-I / 36448
• FlyBaseID: FBgn0086532
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_000023.2
• Gene: ALAS2 / 212
• HGNCID: 397
• Length: 587
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 90/335 - (26%)
• Similarity: 161/335 - (48%)
• Gaps: 37/335 - (11%)

  Fly   101 SHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTMDVHLDLEDRIAKFMGLEEAIVYSYGF- 164
            |::|||.....::|:...::|:::|.|:.|.|...||...|::||..:|:....:.|:::|..|
Human   196 SNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFV 260

  Fly   165 ------STVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVEDLERLLIEQEKR 223
                  .|:|..:|     |..|:.|...:.::.:|:..|.:....|:|||.:.|::||   ||.
Human   261 ANDSTLFTLAKILP-----GCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL---EKS 317

  Fly   224 DQKNPKKAAKTRRFLVA-EGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFGTLGQGGHGVTE 287
            :.|.||        :|| |.::...|.||||.:|..:..:|....|:||..:.|..|..|.|:.|
Human   318 NPKIPK--------IVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGE 374

  Fly   288 HFNVDRDEVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSASLPPMLTQAAISALDRF 352
            ...: ..::|:||..:..:...|||:...:..:.:..|....|:||:.|||||:...|:.::...
Human   375 RDGI-MHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLL 438

  Fly   353 EREPQIFEQLQAKSKTLHQKFLRFSKLTL--RGDEVSPVKHLYLAQPAENFDKELKLLTELADKC 415
            :.     |:.||..:. ||:.::..:..|  ||..|.|.....:.....|    ..|.::|.|..
Human   439 KG-----EEGQALRRA-HQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGN----AALNSKLCDLL 493

  Fly   416 IARGVAVVQA 425
            :::....|||
Human   494 LSKHGIYVQA 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:450240	90/335 (27%)
ALAS2	NP_000023.2	Preseq_ALAS	5..100	CDD:462658
		5aminolev_synth	143..548	CDD:273820	90/335 (27%)