DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt-I and sptl-1

DIOPT Version :9

Sequence 1:	NP_610842.1	Gene:	Spt-I / 36448	FlyBaseID:	FBgn0086532	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001379707.1	Gene:	sptl-1 / 173389	WormBaseID:	WBGene00016020	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	215/451 - (47%)
Similarity:	305/451 - (67%)	Gaps:	17/451 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LETLLLITVIWLLLHRRGGGRRRQ------LTKEEEDRIIADYEPEPLVADTDPNHPLLHTRVVQ 82
            :||||:..:.::::..|  .:|:|      ||:.::|.:|||:.|||||.:|..:||:|:.:...
Worm    12 IETLLVALLAYVVMRNR--SKRQQEKLSKKLTERQKDELIADWTPEPLVPETPQDHPVLNPKYAD 74

  Fly    83 SRVGKRIQVDGHDCLNLGSHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTMDVHLDLEDR 147
            .::.|.:.:||...||:.|.|:|.|:..:.|.:.|.:::.|||||||||||||||:|||||||..
Worm    75 GKMTKDVSIDGEKYLNMASTNFLSFIGVKRIEDRAKQTIFKYGVGSCGPRGFYGTVDVHLDLEKE 139

  Fly   148 IAKFMGLEEAIVYSYGFSTVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVED 212
            :|||||.|||::|||||:||:||||||||:||:|||||.|||||||||.||||.:.:|||||:|.
Worm   140 LAKFMGCEEAVLYSYGFATVSSAIPAYAKKGDVIFVDEGVNFAIQKGLQASRSRVEYFKHNDMEH 204

  Fly   213 LERLLIEQEKRDQKNPKKAAKTRRFLVAEGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFGT 277
            |||||:|||:||:|:||||...|||:|.||:|:|..::||||.::..:.::|:|:|||||.|||.
Worm   205 LERLLLEQEQRDKKDPKKAKSVRRFIVVEGLYVNYADLCPLPKIIEFKWRFKVRVFIDESWSFGV 269

  Fly   278 LGQGGHGVTEHFNVDRDEVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSASLPPMLT 342
            :|:.|.||||||||..::||::.|.:|.::|:.||||||..::..|||||||||.|||||||:|.
Worm   270 IGKTGRGVTEHFNVPMEDVDMVMASLENALASTGGFCVGRSYVVGHQRLSGLGYCFSASLPPLLA 334

  Fly   343 QAAISALDRFEREP---QIFEQLQAKSKTLHQKFLRFSKLTLRGDEVSPVKHLYLAQPAENFDKE 404
            .||..|:...:.||   |...::....:...|..|..||.:|:|...||:||:|.     |.:.|
Worm   335 TAASEAISIIDEEPSRVQKVTEMAINGQKKLQDALSGSKFSLQGCPESPMKHIYY-----NGEDE 394

  Fly   405 LKLLTELADKCIARG-VAVVQAAYLQNRERQPVRPSIRIAVNRLLESSEIDNAFEVIESVS 464
            .|.|....:....:. :.:.:|.||...|...:|||||:.....|...||..|.:.|..|:
Worm   395 EKQLDTFVETVFTKNHLLLTRARYLDKDELFKIRPSIRVMFQHDLTEEEIQRAVDAIRVVA 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	215/451 (48%)
Spt-I	NP_610842.1	BioF	79..463	CDD:223234	192/387 (50%)
sptl-1	NP_001379707.1	AAT_I	9..455	CDD:418510	214/449 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159487
Domainoid	1	1.000	375	1.000	Domainoid score	I462
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4681
Inparanoid	1	1.050	424	1.000	Inparanoid score	I986
Isobase	1	0.950	-	0	Normalized mean entropy	S1053
OMA	1	1.010	-	-		QHG54231
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	1	1.000	-	-		FOG0004733
OrthoInspector	1	1.000	-	-		oto19341
orthoMCL	1	0.900	-	-		OOG6_102559
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3331
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.860