DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spt-I and Alas1

DIOPT Version :9

Sequence 1:	NP_610842.1	Gene:	Spt-I / 36448	FlyBaseID:	FBgn0086532	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001278764.1	Gene:	Alas1 / 11655	MGIID:	87989	Length:	642	Species:	Mus musculus

Alignment Length:	376	Identity:	100/376 - (26%)
Similarity:	170/376 - (45%)	Gaps:	59/376 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HTRVVQSRVGKRIQV-----DGHDCLNLG-------SHNYLGFLEDQEILEEACKSLRKYGVGSC 129
            ||..|...|.:|.|:     |..|.|...       |::|||......:.....::::::|.|:.
Mouse   216 HTYRVFKTVNRRAQIFPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMETVKQHGAGAG 280

  Fly   130 GPRGFYGTMDVHLDLEDRIAKFMGLEEAIVYSYGFSTVASAIPAYAKR--GDLIFVDEAVNFAIQ 192
            |.|...||...|::||..:|...|.:.|:::|..|....|.:...||.  |..|:.|...:.::.
Mouse   281 GTRNISGTSKFHVELEQALADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMI 345

  Fly   193 KGLDASRSTIVFFKHNDVEDLERLLIEQEKRDQKNPKKAAKTRRFLVA-EGIYMNTGEICPLPDL 256
            :|:..||.....|:||||..|..||   ::.|...||        :|| |.::...|.:|||.:|
Mouse   346 QGIRNSRVPKYIFRHNDVNHLRELL---QRSDPSVPK--------IVAFETVHSMDGAVCPLEEL 399

  Fly   257 VALRQKYKLRLFIDESISFGTLGQGGHGVTEHFNVDRD----EVDLISAGMEGSMATVGGFCVGS 317
            ..:..::....|:||..:.|..|..|.|:.     |||    ::|:||..:..:...|||:...:
Mouse   400 CDVAHEFGAITFVDEVHAVGLYGARGGGIG-----DRDGVMPKMDIISGTLGKAFGCVGGYIAST 459

  Fly   318 HFIAEHQRLSGLGYIFSASLPPMLTQAAISALDRFEREPQIFEQLQAKS-KTLHQKFLRFSKLTL 381
            ..:.:..|....|:||:.||||||...|:.::       :|.:..:.:: :..||:.::..:..|
Mouse   460 SLLIDTVRSYAAGFIFTTSLPPMLLAGALESV-------RILKSSEGRALRRQHQRNVKLLRQML 517

  Fly   382 RGDEVSPVKH-------LYLAQPAENFDKELKLLTELADKCIARGVAVVQA 425
            . |...||.|       :.:|..|:|        ||:.|:.:.|....|||
Mouse   518 M-DAGLPVIHCPSHIIPVRVADAAKN--------TEICDELMTRHNIYVQA 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt-I	NP_610842.1	AAT_I	22..468	CDD:302748	100/376 (27%)
Spt-I	NP_610842.1	BioF	79..463	CDD:223234	98/374 (26%)
Alas1	NP_001278764.1	Preseq_ALAS	2..140	CDD:286162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..163
		AAT_I	199..604	CDD:302748	100/376 (27%)
		BioF	199..600	CDD:223234	100/376 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810