DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and WAKL1

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_173063.1	Gene:	WAKL1 / 838181	AraportID:	AT1G16120	Length:	730	Species:	Arabidopsis thaliana

Alignment Length:	673	Identity:	150/673 - (22%)
Similarity:	248/673 - (36%)	Gaps:	200/673 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 ALWDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLC--FEDCQATHLQFCYNDWVLIE 167
            ||..:..|::.| |..:.|           |.:.|..|...:|  :..|||
plant   157 ALMTDTESEILG-CESSCE-----------HRKSGEEVTNLICTGYRCCQA-------------- 195

  Fly   168 EKKERNMFIKSRGHFRL----PNCSSLPHYNASMRRPNCSYIGLTELKES--------------- 213
                           ||    |...::...|:|.....|....||:.:.|
plant   196 ---------------RLPVGRPQAITVNIENSSGGEETCKVAFLTDKRYSPSNVTEPEQFHNNGY 245

  Fly   214 ---EVSYDCRNGNGRF--YMGTMNVSK--SGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNA 271
               |:.:.....|.||  .:|..|:|:  ||........:|.:            ..|.:| ||.
plant   246 VVLELGWYFATSNSRFKSLLGCTNMSRKGSGFSDDNCSCEYDY------------FSGMSY-RNC 297

  Fly   272 GGEEPHPWC---YTVDESVRWQHCDIPMCPDY----VDPNAVDLNTPIKM----EKFFTPSMIFL 325
                   :|   ||.:..:|....|...|...    .|.:.|::..|:.|    .|...|:...:
plant   298 -------YCDYGYTGNPYLRGGCVDTDSCEGNHNCGEDAHCVNMPGPMSMCRPNPKITKPTKPPV 355

  Fly   326 LAGI-----GFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETL 385
            |.||     |.|..|.|..:..|:.|..                            |:|.|::..
plant   356 LQGILIGLSGLVFFVGLFWLFKLIKKRR----------------------------NINRSKKFF 392

  Fly   386 GGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQG 450
            ..||..       .::...|.....|.::.:.:..:.:....|..::            |.||||
plant   393 KRNGGL-------LLKQQLTTKDGNVEMSKIFSSKELRKATDNFSID------------RVLGQG 438

  Fly   451 AFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGR 515
            ..|.|::    |::.|..  :||||..|....|:|: :|..|..||::.:|.|||:|||.|....
plant   439 GQGTVYK----GMLVDGS--IVAVKRSKVVDEDKME-EFINEIVLLSQINHRNIVKLLGCCLETE 496

  Fly   516 PMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYL-SERKF--V 577
            ...|::||:..|||.:.|        |. .:.|.....|:. |::|..||..:.|: |...|  .
plant   497 VPILVYEYIPNGDLFKRL--------HD-ESDDYTMTWEVR-LRIAIEIAGALTYMHSAASFPIF 551

  Fly   578 HRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPI-----RWMPLESILYNKFSLE 637
            |||:.|.|.|::|....|::|||.|..:.|      |:.....:     .:|..|..|.::::.:
plant   552 HRDIKTTNILLDEKYRAKVSDFGTSRSVTL------DQTHLTTLVAGTFGYMDPEYFLSSQYTHK 610

  Fly   638 SDVWAYGICLWEVFSFALQPYFGLTHEE-------VIKYIKEGNVLGCPD---------NTPLSV 686
            |||:::|:.|.|:.: ..:|...:..||       .::.:||..|:...|         ...::|
plant   611 SDVYSFGVVLVELIT-GEKPLSRVRSEEGRGLATHFLEAMKENRVIDIIDIRIKDESKLEQVMAV 674

  Fly   687 YALMRRCWNRKPSERPGFAEINH 709
            ..|.|:|.|||...||...|:::
plant   675 AKLARKCLNRKGKNRPNMKEVSN 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	21/112 (19%)
		KR	217..299	CDD:214527	19/88 (22%)
		PTKc_Musk	435..713	CDD:133181	85/299 (28%)
		Pkinase_Tyr	441..707	CDD:285015	84/289 (29%)
WAKL1	NP_173063.1	GUB_WAK_bind	36..153	CDD:372835
		WAK	184..286	CDD:254827	22/130 (17%)
		PKc_like	435..702	CDD:389743	84/287 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I2087
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050