DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and CRK11

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_194050.2	Gene:	CRK11 / 828418	AraportID:	AT4G23190	Length:	667	Species:	Arabidopsis thaliana

Alignment Length:	557	Identity:	124/557 - (22%)
Similarity:	205/557 - (36%)	Gaps:	167/557 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 SSLPHYNA--SMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHK 250
            ||..||:|  ::..|..:...|.:......|.||.|                  |.|
plant   178 SSDNHYSADSAVLTPLLNIYALMQCTPDLSSGDCEN------------------CLR-------- 216

  Fly   251 HFQPPLVFHQLLEGENYC-RNAGGEEPHPWCYTVDESVRWQHCDI----------------PMCP 298
                    ...::.::.| :..||....|.|:     :||   |:                |..|
plant   217 --------QSAIDYQSCCSQKRGGVVMRPSCF-----LRW---DLYTYSNAFDNLTVASPPPEPP 265

  Fly   299 DYVDPNAVDLNTPIKME-KFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATA 362
            ..|...|.|.:.|...: |..:..::..:.....:||:.|.::..::::  :.|.|.:....:.:
plant   266 VTVPQPAGDQDNPTNNDSKGISAGVVVAITVPTVIAILILLVLGFVLFR--RRKSYQRTKTESES 328

  Fly   363 ECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKP 427
            :.|                                                ||.:.|.|.|
plant   329 DIS------------------------------------------------TTDSLVYDFK---- 341

  Fly   428 NARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFERE 492
                 .:|...........||:|.||.|::    |.:.:..|  ||||.| ...|.|...:|..|
plant   342 -----TIEAATNKFSTSNKLGEGGFGAVYK----GKLSNGTD--VAVKRL-SKKSGQGTREFRNE 394

  Fly   493 ACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHL 557
            |.|:.:..|.|:|||||.|.......|::|::....|..||          ...:.:.||:....
plant   395 AVLVTKLQHRNLVRLLGFCLEREEQILIYEFVHNKSLDYFL----------FDPEKQSQLDWTRR 449

  Fly   558 LQMAANIAAGMLYL---SERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFI 619
            .::...||.|:|||   |..|.:||||...|.|::..|..|||||||: .|:..:..:|:.|...
plant   450 YKIIGGIARGILYLHQDSRLKIIHRDLKASNILLDADMNPKIADFGLA-TIFGVEQTQGNTNRIA 513

  Fly   620 -PIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTP 683
             ...:|..|..::.::|::||::::|:.:.|:.|       |..:..|.: :.|.:..|     .
plant   514 GTYAYMSPEYAMHGQYSMKSDIYSFGVLVLEIIS-------GKKNSGVYQ-MDETSTAG-----N 565

  Fly   684 LSVYALMRRCW-NRKPSE--RPGFA------EINHCI 711
            |..||  .|.| |:.|.|  .|.|.      |:..||
plant   566 LVTYA--SRLWRNKSPLELVDPTFGRNYQSNEVTRCI 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	7/25 (28%)
		KR	217..299	CDD:214527	14/98 (14%)
		PTKc_Musk	435..713	CDD:133181	85/290 (29%)
		Pkinase_Tyr	441..707	CDD:285015	81/278 (29%)
CRK11	NP_194050.2	Stress-antifung	26..125	CDD:279926
		Stress-antifung	<168..244	CDD:279926	20/107 (19%)
		TyrKc	355..624	CDD:197581	84/279 (30%)
		STKc_IRAK	356..625	CDD:270968	84/278 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I2087
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050