DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and CRK37

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_192359.1	Gene:	CRK37 / 825780	AraportID:	AT4G04500	Length:	646	Species:	Arabidopsis thaliana

Alignment Length:	672	Identity:	135/672 - (20%)
Similarity:	233/672 - (34%)	Gaps:	198/672 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GWKNEQVTTALWDELISDLTGLCREAAEK----------MLCAYAFPNCHMEGGRAVKAPLCFE- 149
            |::.:...|.| :.:|.|....|....|.          :.|:..:.| |...|:....|....
plant    83 GYEKQACKTCL-EHVIEDTKSKCPRQKESFSWVTDEFDDVSCSLRYTN-HSTLGKLELLPNTINP 145

  Fly   150 -----DCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTE 209
                 |.:..::.....:|:.:   ..|.:...|...    |.|.|.:|:|:.          ||
plant   146 NPNSIDSKFNNMAMFSQEWIAM---VNRTLEAASTAE----NSSVLKYYSATR----------TE 193

  Fly   210 LKESEVSY-------------------DCRNGNGRFYMGTMNVSKSGIPCQ-RWDTQYPHKHFQP 254
            ..:....|                   :|.|...:.:.|......|...|. |||.
plant   194 FTQISDVYALMQCVPDLSPGNCKRCLRECVNDFQKQFWGRQGGGVSRPSCYFRWDL--------- 249

  Fly   255 PLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFT 319
                                  :|:....|..||     :|..|.......:|..   :.||.|.
plant   250 ----------------------YPYYRAFDNVVR-----VPAPPPQASSTIIDYG---RDEKSFQ 284

  Fly   320 PSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRET 384
            .|.|.::.   ..:::.|.:.::|::...:.:.::                      .:|...::
plant   285 GSNIAIIV---VPSVINLIIFVVLIFSWKRKQSHT----------------------IINDVFDS 324

  Fly   385 LGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQ 449
            ..|.               :.:..:...:.|.||         |..||            ..|||
plant   325 NNGQ---------------SMLRFDLRMIVTATN---------NFSLE------------NKLGQ 353

  Fly   450 GAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALG 514
            |.||.|::    |::|..::  :|||.|: ..|.|..|:|:.|..||....|.|:|:|||.|...
plant   354 GGFGSVYK----GILPSGQE--IAVKRLR-KGSGQGGMEFKNEVLLLTRLQHRNLVKLLGFCNEK 411

  Fly   515 RPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYL---SERKF 576
            ....|::|::....|..|:          ...:.|..|.......:...:|.|:|||   |:.:.
plant   412 DEEILVYEFVPNSSLDHFI----------FDEEKRRVLTWDVRYTIIEGVARGLLYLHEDSQLRI 466

  Fly   577 VHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFI-PIRWMPLESILYNKFSLESDV 640
            :||||...|.|::..|..|:||||:: :::..|..:|..:..: ...:|..|...|.:||.:|||
plant   467 IHRDLKASNILLDAEMNPKVADFGMA-RLFDMDETRGQTSRVVGTYGYMAPEYATYGQFSTKSDV 530

  Fly   641 WAYGICLWEVFSFALQPYFGLTHEE--------VIKYIKEG------NVLGCPDNTPLSVYALMR 691
            :::|:.|.|:.|...........||        |.|...||      :.|..|.|. :|:..:|:
plant   531 YSFGVMLLEMISGKSNKKLEKEEEEEEEELPAFVWKRWIEGRFAEIIDPLAAPSNN-ISINEVMK 594

  Fly   692 ------RCWNRKPSERPGFAEI 707
                  .|.....|:||....|
plant   595 LIHIGLLCVQEDISKRPSINSI 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	23/131 (18%)
		KR	217..299	CDD:214527	14/101 (14%)
		PTKc_Musk	435..713	CDD:133181	81/297 (27%)
		Pkinase_Tyr	441..707	CDD:285015	80/289 (28%)
CRK37	NP_192359.1	Stress-antifung	29..127	CDD:279926	8/44 (18%)
		Stress-antifung	168..248	CDD:279926	16/93 (17%)
		Pkinase	345..617	CDD:278497	83/303 (27%)
		STKc_IRAK	351..622	CDD:270968	81/285 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I2087
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050