DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and Musk

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_112323.2	Gene:	Musk / 81725	RGDID:	3211	Length:	868	Species:	Rattus norvegicus

Alignment Length:	687	Identity:	262/687 - (38%)
Similarity:	350/687 - (50%)	Gaps:	163/687 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EREENGYCAPYSGKVCKEYLT--GQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKM 125
            ::|..||||.|.|:||...|.  ..|:::...|......|.:....|:|| ..::.|||.|||.:
  Rat   310 QKESKGYCAQYRGEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWNEL-KAVSPLCRPAAEAL 373

  Fly   126 LCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHF-RLPNCSS 189
            ||.:.|..| ..|......|:|.|.|.|....||..:|:.:|.|..|.:: :|..|| .:|.||.
  Rat   374 LCNHLFQEC-SSGVLPTPMPICREYCLAVKELFCAKEWLAMEGKTHRGLY-RSGMHFLPVPECSK 436

  Fly   190 LPHYNASMRR-PN-CSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHF 252
            ||    ||.: |. |:.:...:.|:..:                             |.:|....
  Rat   437 LP----SMHQDPTACTRLPYLDYKKENI-----------------------------TTFPSITS 468

  Fly   253 QPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKF 317
            ..|.|                                   |||             |.|.....|
  Rat   469 SKPSV-----------------------------------DIP-------------NLPASTSSF 485

  Fly   318 -FTP--SMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLN 379
             .:|  ||..:::.:...|:..| |.|..:|...:.:::.                        |
  Rat   486 AVSPAYSMTVIISIMSCFAVFAL-LTITTLYCCRRRREWK------------------------N 525

  Fly   380 TSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTN--VSDAKGTKP---------NARLEK 433
            ..||                        |..|.|||:.:  :.|.....|         |.:|..
  Rat   526 KKRE------------------------SAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLS 566

  Fly   434 LEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAE 498
            |||||.:|.|||.:|:||||||||||||||:|.:...:|||||||::||..||.||:|||.|:||
  Rat   567 LEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAE 631

  Fly   499 FDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYA----TH-QAPTQDRLQ------L 552
            ||:||||:||||||:|:||||||||||.|||:||||:.||:.    :| ...|:.|:.      |
  Rat   632 FDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPL 696

  Fly   553 NELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDEND 617
            :....|.:|..:||||.||||||||||||||||||:.|:|.|||||||||..||..||||.|.||
  Rat   697 SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGND 761

  Fly   618 FIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNT 682
            .|||||||.|||.||:::.||||||||:.|||:||:.||||:|:.|||||.|:::||:|.||:|.
  Rat   762 AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENC 826

  Fly   683 PLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESE 719
            ||.:|.|||.||::.|::||.|..|:..:|.....:|
  Rat   827 PLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	49/149 (33%)
		KR	217..299	CDD:214527	7/81 (9%)
		PTKc_Musk	435..713	CDD:133181	178/288 (62%)
		Pkinase_Tyr	441..707	CDD:285015	173/276 (63%)
Musk	NP_112323.2	IgI_1_MuSK	28..117	CDD:409562
		Ig strand B	45..49	CDD:409562
		Ig strand C	58..62	CDD:409562
		Ig strand E	82..86	CDD:409562
		Ig strand F	96..101	CDD:409562
		Ig strand G	110..113	CDD:409562
		IgI_2_MuSK	122..209	CDD:409560
		Ig strand B	138..142	CDD:409560
		Ig strand C	151..155	CDD:409560
		Ig strand E	173..177	CDD:409560
		Ig strand F	187..192	CDD:409560
		Ig strand G	201..204	CDD:409560
		Ig_3	218..286	CDD:404760
		Ig strand A'	222..225	CDD:409353
		Ig strand B	229..236	CDD:409353
		Ig strand C	242..247	CDD:409353
		Ig strand C'	250..252	CDD:409353
		Ig strand D	258..262	CDD:409353
		Ig strand E	268..272	CDD:409353
		Ig strand F	278..286	CDD:409353
		CRD_TK_ROR_related	313..457	CDD:143578	49/150 (33%)
		PTKc_Musk	568..857	CDD:133181	178/288 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352710
Domainoid	1	1.000	361	1.000	Domainoid score	I925
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4084
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1532
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0008235
OrthoInspector	1	1.000	-	-		oto97931
orthoMCL	1	0.900	-	-		OOG6_110114
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.800