DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and Ptk7

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_006524986.1	Gene:	Ptk7 / 71461	MGIID:	1918711	Length:	1088	Species:	Mus musculus

Alignment Length:	726	Identity:	187/726 - (25%)
Similarity:	296/726 - (40%)	Gaps:	174/726 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CVFLFASATHANSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEY---------LTGQV 86
            ||    |:|.|.|:.|           :...:..|:..:..|...:.|.|:         .||:
Mouse   499 CV----SSTPAGSIEA-----------QARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGR- 547

  Fly    87 WYSLEDPTGGWKNEQVTTALWDELISDLTG------LCREAAEKMLCAYAFPNCHMEGGRAVKAP 145
                |.||..|.....::.  .|.::|..|      :.|:.|....|.     ...|....::|
Mouse   548 ----EKPTVKWVRADGSSL--PEWVTDNAGTLHFARVTRDDAGNYTCI-----ASNEPQGQIRA- 600

  Fly   146 LCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTEL 210
                     |:|.....::..:.:.||....  :||..|..|.:     ....:|...:.|...:
Mouse   601 ---------HVQLTVAVFITFKVEPERTTVY--QGHTALLRCEA-----QGDPKPLIQWKGKDRI 649

  Fly   211 KESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKH-FQ-PPLVFHQLL--EGENYCRNA 271
                                ::.:|.|          |..| || ..||.|.:.  :..:|...|
Mouse   650 --------------------LDPTKLG----------PRMHIFQNGSLVIHDVAPEDSGSYTCIA 684

  Fly   272 GGEEPHPWCYTVDESVRWQHCDIPMC----PDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFV 332
            |            .|...:|.:.|:.    |...|........|.||.:....|   :.|.:.::
Mouse   685 G------------NSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQTIGLS---VGAAVAYI 734

  Fly   333 AIVTLHLMILLVYKLSKHKDYSQPAG-AATAECSVSMRGGGDCGGNLNTSRETLGG---NGNTNT 393
             |..|.||.....:....:...||.| ....||             ||      ||   ||
Mouse   735 -IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMEC-------------LN------GGPLQNG---- 775

  Fly   394 LAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQA 458
                   :.:|.|... ||||::.:...|...:.:|. :::.:||..:..:.:||:..||.||.|
Mouse   776 -------QPSAEIQEE-VALTSLGSGPPATNKRHSAG-DRMHFPRASLQPITTLGKSEFGEVFLA 831

  Fly   459 RAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEY 523
            :|.|:.....:.||.||.|: ...:|.|:||.||..:..:.:|.|:|||||:|....|..::.||
Mouse   832 KAQGVEEGATETLVLVKSLQ-SRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEY 895

  Fly   524 MAPGDLSEFLR---------ACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHR 579
            :..|||.:|||         ...|.:|.|.             :.:.:.:|.||.:||..:|||:
Mouse   896 VDLGDLKQFLRISKNKDEKLKSQPLSTKQK-------------VALCSQVALGMEHLSNNRFVHK 947

  Fly   580 DLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYG 644
            |||.|||||:....||::..|||..:|..:||. ....::|:|||..|::|...||.:|||||:|
Mouse   948 DLAARNCLISAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAVLEGDFSTKSDVWAFG 1011

  Fly   645 ICLWEVFSFALQPYFGLTHEEVIKYIKEGNV-LGCPDNTPLSVYALMRRCWNRKPSERPGFAEIN 708
            :.:||||:....|:.|...:||:..::.|.. |..|:..|..:|.||:|||...|.:||.|:||.
Mouse  1012 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIA 1076

  Fly   709 HCIQHSIAESE 719
            ..:..|.|:|:
Mouse  1077 STLGDSPADSK 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	27/159 (17%)
		KR	217..299	CDD:214527	15/89 (17%)
		PTKc_Musk	435..713	CDD:133181	104/287 (36%)
		Pkinase_Tyr	441..707	CDD:285015	100/275 (36%)
Ptk7	XP_006524986.1	IGc2	63..125	CDD:197706
		Ig2_PTK7	164..240	CDD:143237
		Ig_3	245..320	CDD:372822
		IGc2	354..416	CDD:197706
		Ig	430..516	CDD:386229	7/31 (23%)
		Ig	521..606	CDD:386229	19/106 (18%)
		Ig	627..687	CDD:319273	16/106 (15%)
		PTK_CCK4	808..1081	CDD:133178	104/287 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810