DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and Hgfac

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_445772.1	Gene:	Hgfac / 58947	RGDID:	70909	Length:	653	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	102/514 - (19%)
Similarity:	158/514 - (30%)	Gaps:	186/514 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SGKVCK---EYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREA-----AEKMLCAYA 130
            ||:.|:   .| .|::.:|.......::....||..:|.  ....|.|.||     ...:|...|
  Rat   101 SGQPCRFPFRY-GGRMLHSCSSEGSAYRKWCATTHNYDR--DRAWGYCAEATLPVEGPAVLDPCA 162

  Fly   131 FPNCHMEGGRA----------VKAPLCF--EDCQATHLQFCYND-----------WVLIEEKKER 172
            ...| :.||..          ...||.|  :||..   :.|:::           |..:.|
  Rat   163 SGPC-LNGGTCSSTQDHVSYHCACPLAFTGKDCGT---EKCFDETRYEYFEVGDHWARVSE---- 219

  Fly   173 NMFIKSRGHFRLPNCSSL--------PHYNASMRRP-----NCSYI---GLTELKESEVSY---- 217
                   ||  :..||.:        .|:.|.:..|     .|..|   | |.:....:.|
  Rat   220 -------GH--VEQCSCIEGQARCEDTHHTACLSSPCLNGGTCHLIVGTG-TSICACPLGYAGRF 274

  Fly   218 -------DCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEG---ENYCRNAG 272
                   .|..|||..|.|..:.|.||:.|..|::...::......|....|.|   ..||||..
  Rat   275 CNIVPTERCFLGNGTEYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPD 339

  Fly   273 GEEPHPWCYTV-DESVRWQHCDIPMC----------PDYVD--PNAVDLNTPI-----KMEKFFT 319
            .:| .||||.| |.::.|::|.:..|          |:.:.  |.:.....|.     |...|..
  Rat   340 KDE-RPWCYVVKDSALSWEYCRLAACESLARVHSRIPEVLATLPESTSTARPTCGKRHKKRTFLR 403

  Fly   320 PSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRET 384
            |.:|.     |..::...|..:..:|                       .|.|.|.|:|
  Rat   404 PRIIG-----GSSSLPGSHPWLAAIY-----------------------IGNGFCAGSL------ 434

  Fly   385 LGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQ 449
                                 :|: |    .|.:.:....:.|         ||..|..|  |||
  Rat   435 ---------------------VHT-C----WVVSAAHCFSSSP---------PRDSITVV--LGQ 462

  Fly   450 GAFGRVFQARAPGLV-------------PDQEDLLVAVKMLKDDASDQMQMDFEREACL 495
            ..|.|.........:             |:..| ||.:::.|......::..|.:..||
  Rat   463 HFFNRTTDVTQTFAIEKYVPYTLYSVFNPNDHD-LVLIRLKKKGERCAVRSQFVQPICL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	37/184 (20%)
		KR	217..299	CDD:214527	29/106 (27%)
		PTKc_Musk	435..713	CDD:133181	17/74 (23%)
		Pkinase_Tyr	441..707	CDD:285015	15/68 (22%)
Hgfac	NP_445772.1	FN2	99..145	CDD:128373	10/46 (22%)
		EGF_CA	159..194	CDD:238011	7/35 (20%)
		FN1	197..237	CDD:238018	7/52 (13%)
		EGF	242..274	CDD:278437	6/32 (19%)
		Kringle	283..364	CDD:278480	27/81 (33%)
		Tryp_SPc	405..639	CDD:214473	30/188 (16%)
		Tryp_SPc	406..641	CDD:238113	30/187 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000